14
10
↑14
↓10
—0
Evidence suggests Melatonin mayincreaseDiabetes.
32 studies (24 claims)
Emerging evidence
Typical effective dose 10 (10–10) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| mutations and/or genetic polymorphisms of the melatonin receptors | Increases - are associated with an increased risk | developing type 2 diabetes | Human | — | Not specified | Chronomedicine and type 2 diabetes: shining some light on melatonin.cited 44× |
| reduced melatonin levels | Increases - are associated with an increased risk | developing type 2 diabetes | Human | — | Not specified | Chronomedicine and type 2 diabetes: shining some light on melatonin.cited 44× |
| melatonin | No effect - hinders | development of type 2 diabetes | HumanAnimalMolecular | — | Not specified | Experimental and clinical aspects of melatonin and clock genes in diabetes. |
| melatonin | No effect - hinders | development of type 2 diabetes | HumanAnimalMolecular | — | Not specified | Experimental and clinical aspects of melatonin and clock genes in diabetes. |
| melatonin | No effect - seems to be well funded | diabetes | Human | — | Not specified | Clinical uses of melatonin: evaluation of human trials.cited 219× |
| melatonin | Decreases - has an antidiabetic effect | diabetes | Molecular | several animal models | Pharmacological doses mentioned (specific amounts not provided). | Melatonin in energy control: Circadian time-giver and homeostatic monitor.cited 7× |
| melatonin | No effect - may influence | diabetes and associated metabolic disturbances | Molecular | — | — | Role of melatonin on diabetes-related metabolic disorders. |
| blocking the melatonin-induced inhibition of insulin secretion | No effect - may be a novel therapeutic avenue | type 2 diabetes | Molecular | — | — | Role of melatonin on diabetes-related metabolic disorders. |
| melatonin | Decreases - can alleviate | diabetes-induced cognitive dysfunction | Human | — | Not specified | The Mechanism and Treatment of Cognitive Dysfunction in Diabetes: A Review. |
| melatonin | Decreases - hinders | the development of type 2 diabetes | HumanAnimalMolecular | — | — | Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes. |
| melatonin | Increases - associated with an increased risk | type 2 diabetes | Human | common G-allele in the MTNR1B locus | Four doses of 10 mg oral melatonin. | Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.cited 17× |
| melatonin | No effect - has recently seen an unexpected extension of its functional implications toward | type 2 diabetes development | HumanAnimal | — | Not available | Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. |
| melatonin | No effect - has recently seen an unexpected extension of its functional implications toward | type 2 diabetes development | HumanAnimal | — | Not available | Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. |
| melatonin | No effect - may be involved in the pathogenesis | type 2 diabetes mellitus | Animal | — | — | Distribution of melatonin receptors in murine pancreatic islets. |
| Melatonin | Increases - increased | type 2 diabetes risk | HumanMolecular | human carriers of the MTNR1B G allele | — | Supraspinal melatonin MT |
| melatonin | Decreases - identified as potentially beneficial | type 2 diabetes treatment or prevention | Human | — | Not specified | Nutritional supplements and their effect on glucose control.cited 15× |
| exogenous melatonin | Increases - play a role | diabetes and associated metabolic disturbances | Human | — | Not specified | Melatonin and glucose metabolism: clinical relevance.cited 31× |
| single nucleotide polymorphism of the human melatonin receptor 1B | Increases - causally linked to an increased risk | developing type 2 diabetes | Human | — | Not specified | Melatonin and glucose metabolism: clinical relevance.cited 31× |
| endogenous melatonin | Increases - play a role | diabetes and associated metabolic disturbances | Human | — | Not specified | Melatonin and glucose metabolism: clinical relevance.cited 31× |
| variations in melatonin receptor 1B | Increases - may be at higher risk | type 2 diabetes | Human | Individuals | Not available | A systematic review of variations in circadian rhythm genes and type 2 diabetes.cited 1× |
| impaired melatonin secretion | Increases - promotes | type-2 diabetes | Human | — | Not specified | Physiological and pharmacological perspectives of melatonin.cited 30× |
| exogenous melatonin treatment | Decreases - has shown a potent effect in alleviating | diabetes | Human | cell lines, rodent models, and diabetic patients | Not specified | Diabetes mellitus and melatonin: Where are we?cited 33× |
| Common variants in the melatonin receptor type 1B (MTNR1B) locus | Increases - increase the risk of | type 2 diabetes | Molecular | — | — | MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. |
| melatonin receptor genetic polymorphisms | Increases - implicated in | type 2 diabetes | HumanMolecular | — | Not specified | Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. |
| melatonin receptor genetic polymorphisms | Increases - implicated in | type 2 diabetes | HumanMolecular | — | Not specified | Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. |
| melatonin supplementation | No effect - appears as a supplement capable of helping with | diabetes | Human | — | Not specified in the abstract. | Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.cited 25× |
| melatonin supplementation | Decreases - showed benefits in | diabetes parameters | Human | — | Not specified in the abstract. | Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.cited 25× |
| melatonin supplementation | Decreases - was useful for reducing | diabetes parameters | Human | — | Not specified in the abstract. | Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.cited 25× |
| dysregulated signaling of melatonin | No effect - implicated in | development of type 2 diabetes mellitus | HumanAnimalMolecular | — | Not specified | Monoamines' role in islet cell function and type 2 diabetes risk.cited 5× |
| melatonin and insulin coadministration | Decreases - abolished many of the deleterious effects | type 1 diabetes on rat renal function | Animal | rats | — | Coadministration of Melatonin and Insulin Improves Diabetes-Induced Impairment of Rat Kidney Function. |