6
15
↑6
↓15
—0
Evidence suggests Melatonin maydecreaseCell death.
25 studies (21 claims)
Moderate consensus
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin | Increases - induced | apoptosis and autophagy cell death progression | HumanAnimalMolecular | ELT3 cells | — | Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation. |
| melatonin | Increases - trigger apoptotic cell death | apoptotic cell death | Human | osteosarcoma | Not specified | Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations.cited 7× |
| melatonin | Increases - appears to affect | cancer cell death | HumanMolecular | — | Not available. | Molecular Interactions of Autophagy with the Immune System and Cancer.cited 25× |
| melatonin | No effect - regulating | programmed cell death | HumanMolecular | — | Not available. | Molecular Interactions of Autophagy with the Immune System and Cancer.cited 25× |
| melatonin | Decreases - preventing | cell death | Molecular | cardiac cells | Not specified | Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication.cited 1× |
| melatonin | No effect - impacts | cell death | Molecular | — | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Decreases - attenuated | cell death | Human | — | Not specified | Roles of melatonin and its receptors in cardiac ischemia-reperfusion injury.cited 23× |
| melatonin (Mel) | Decreases - inhibiting | mitochondrial cell death pathways | HumanMolecular | — | Not specified. | Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review.cited 18× |
| melatonin (Mel) | Decreases - preventing | oxidative stress and cell death | HumanMolecular | neurons exposed to Aβ-induced neurotoxicity | Not specified. | Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review.cited 18× |
| melatonin | Decreases - efficacy for preventing | neuronal cell death | Human | animal models of PD employing neurotoxins | — | Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection. |
| melatonin | Decreases - protecting and reducing oxidative stress in mitochondria, can normalize homeostasis and mitochondrial function and ultimately prevent apoptosis and cell death | oxidative stress in mitochondria, homeostasis, mitochondrial function, apoptosis, cell death | Human | — | Not specified | Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity.cited 14× |
| melatonin | No effect - affecting | programmed cell death such as apoptosis and autophagy | Molecular | retinal cells | Not specified | Melatonin and retinal cell damage: molecular and biological functions. |
| melatonin | Decreases - able to alleviate | radiation-induced cell death | HumanMolecular | — | Not specified | Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?cited 19× |
| melatonin | Decreases - reduces | vascular endothelial cell death | Human | diabetic patients | Not specified | New insights into the role of melatonin in diabetic cardiomyopathy.cited 14× |
| high concentrations of melatonin | Increases - induce cell death | cell death | Molecular | some types of tumors | Not specified (low and high concentrations mentioned, but exact amounts not provided). | Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration.cited 24× |
| melatonin treatment | Decreases - exhibited protective effect against | asphyxial CA/CPR-induced Purkinje cell death | Animal | vehicle-treated asphyxial CA/CPR rats | — | Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress. |