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Evidence suggests Melatonin maydecreaseBlood glucose.
10 studies (11 claims)
Moderate consensus
Typical effective dose 3 (3–3) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| pretreatment of hUC-MSCs with melatonin | Decreases - significantly reduced | blood glucose levels | AnimalMolecular | mice | — | Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. |
| melatonin | Decreases - decreases | blood glucose levels | Human | — | Not Assessed | Melatonin: A Molecule for Reducing Breast Cancer Risk.cited 39× |
| melatonin (3 mg) | No effect - significant absolute difference | breakfast blood glucose levels | Human | patients with type 2 diabetes mellitus (T2DM) | 3 mg melatonin, administered nightly for 7 days. | Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study.cited 4× |
| melatonin | Decreases - is probably reduced more | fasting blood glucose | Human | — | Not specified | Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries.cited 9× |
| melatonin | Decreases - alleviated | serum fasting blood glucose and lipid levels | Animal | streptozotocin-induced diabetic rats | — | Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation. |
| melatonin supplementation | Decreases - significantly reduced | fasting blood glucose | Human | — | Not specified in the abstract. | The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 33× |
| melatonin supplementation | Decreases - significantly reduced | fasting blood glucose | Human | patients with metabolic diseases | Not specified in the abstract. | The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 33× |
| melatonin supplementation | Decreases - showed significant results for | fasting blood glucose | Human | — | Not specified in the abstract. | Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.cited 25× |
| melatonin receptor signaling | Increases - highlight a diurnal contribution | daily regulation of blood glucose levels | Animal | — | — | Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. |
| melatonin receptor knockout | No effect - altered | blood glucose concentrations | AnimalMolecular | wild-type vs receptor knockout mice of different ages (6 wk and 8-12 months old) | — | Influence of melatonin receptor signalling on parameters involved in blood glucose regulation. |
| melatonin receptor knockout (MT1) | Decreases - decreased | blood glucose levels | AnimalMolecular | MT1-knockout mice (8-12 months old) | — | Influence of melatonin receptor signalling on parameters involved in blood glucose regulation. |
| melatonin receptor knockout (double) | Decreases - decreased | blood glucose levels | AnimalMolecular | double-knockout mice (8-12 months old) | — | Influence of melatonin receptor signalling on parameters involved in blood glucose regulation. |