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Evidence suggests Melatonin maydecreaseAnxiety.
12 studies (13 claims)
Typical dose 25 mg
Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.
12 of 14
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin | Decreases - has proven anxiolytic effects | anxiety | Human | — | 25 mg melatonin. | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.cited 16× |
| melatonin | Decreases - alleviate | anxiety | Human | PD patients | Not specified | Chronotherapies for Parkinson's disease.cited 30× |
| melatonin | Decreases - reduced | anxiety | Human | human participants | — | Differential Function of Melatonin MT |
| melatonin | Decreases - reducing | anxiety | Human | critical care patients | Not specified | COVID-19: Melatonin as a potential adjuvant treatment.cited 389× |
| melatonin | Decreases - reducing | anxiety | Human | critical care patients | Not specified | Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed.cited 45× |
| melatonin | No effect - No significant changes were observed in | anxiety | Human | menopausal women | 1 mg to 5 mg (varied by study). | Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials.cited 9× |
| melatonin | Decreases - showed anxiolytic potential | anxiety | Human | patients that were submitted to dental procedures | Not specified | Melatonin as an adjunctive treatment on dental procedures: A systematic review.cited 3× |
| melatonin | Decreases - effectiveness as an anxiolytic medication has been confirmed | anxiety | Human | adults | — | Melatonin for pre-medication in children: a systematic review.cited 11× |
| melatonin | No effect - efficacy is unclear | anxiety | Human | paediatric population | — | Melatonin for pre-medication in children: a systematic review.cited 11× |
| melatonin | No effect - Evidence to support anxiolytic properties is conflicting | anxiety | Human | children | — | Melatonin for pre-medication in children: a systematic review.cited 11× |
| melatonin | Decreases - reductions in | anxiety | Human | participants with TBI-induced sleep disturbance | — | The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review.cited 8× |
| melatonin | No effect - effect on | anxiety | Human | participants | 25 mg melatonin administered rectally daily. | Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial.cited 2× |