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Evidence suggests Melatonin maydecreaseAnxiety.
49 studies (63 claims)
Moderate consensus
Typical effective dose 5 (2.25–10) mgacross 22 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| oral melatonin 0.3 mg kg-1 | No effect - were similar | pre-operative anxiety | Human | Children in the age group of 3 to 8 years who received sevoflurane anaesthesia for elective ambulatory procedures | 0.3 mg/kg of melatonin, administered orally as a single premedication dose. | Oral melatonin as part of multimodal anxiolysis decreases emergence delirium in children whereas midazolam does not: A randomised, double-blind, placebo-controlled study.cited 18× |
| melatonin 20 mg | No effect - found to be nonsignificant | ESAS anxiety | Human | patients with breast cancer undergoing RT | 20 mg orally, starting the night before radiotherapy initiation until 2 weeks post-radiotherapy. | Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial.cited 6× |
| melatonin | No effect - effect on | anxiety | Human | participants | 25 mg melatonin administered rectally daily. | Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial.cited 2× |
| melatonin | Decreases - has proven anxiolytic effects | anxiety | Human | — | 25 mg melatonin. | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.cited 16× |
| melatonin | Decreases - has a preventive effect | anxiety symptoms | Human | patients after acute coronary syndrome | 25 mg melatonin. | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.cited 16× |
| melatonin | Decreases - alleviate | anxiety | Human | PD patients | Not specified | Chronotherapies for Parkinson's disease.cited 30× |
| melatonin | Decreases - reducing | anxiety | Human | critical care patients | Not specified | COVID-19: Melatonin as a potential adjuvant treatment.cited 389× |
| melatonin | Decreases - showed anxiolytic potential | anxiety | Human | patients that were submitted to dental procedures | Not specified | Melatonin as an adjunctive treatment on dental procedures: A systematic review.cited 3× |
| melatonin | Decreases - effectiveness as an anxiolytic medication has been confirmed | anxiety | Human | adults | — | Melatonin for pre-medication in children: a systematic review.cited 11× |
| melatonin | No effect - efficacy is unclear | anxiety | Human | paediatric population | — | Melatonin for pre-medication in children: a systematic review.cited 11× |
| melatonin | No effect - Evidence to support anxiolytic properties is conflicting | anxiety | Human | children | — | Melatonin for pre-medication in children: a systematic review.cited 11× |
| melatonin | Decreases - reductions in | anxiety | Human | participants with TBI-induced sleep disturbance | — | The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review.cited 8× |
| melatonin | Decreases - reduced | anxiety | Human | human participants | — | Differential Function of Melatonin MT |
| melatonin | No effect - No significant changes were observed in | anxiety | Human | menopausal women | 1 mg to 5 mg (varied by study). | Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials.cited 9× |
| melatonin | Decreases - reducing | anxiety | Human | critical care patients | Not specified | Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed.cited 45× |
| melatonin | Decreases - reduction in | anxiety and pain | Human | — | Not specified | Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.cited 147× |
| repeated administration of melatonin | Decreases - may reduce | anxiety | Human | — | Not specified | Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.cited 147× |
| melatonin | Decreases - could be more effective than oxazepam in improving | anxiety levels | Human | patients presenting with STEMI | 3 mg every night | Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial.cited 9× |
| melatonin | Decreases - significantly in favor of | lowering the anxiety levels | Human | STEMI patients managed with primary PCI | 3 mg every night | Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial.cited 9× |
| melatonin | Increases - significantly improved | anxiety scores | Human | BMS patients | 12 mg/day | Melatonin Treatment in Patients with Burning Mouth Syndrome: A Triple-Blind, Placebo-Controlled, Crossover Randomized Clinical Trial.cited 18× |
| melatonin | No effect - no evidence of a difference | anxiety scores | Human | adults in the intensive care unit | Not specified (doses varied between studies). | Melatonin for the promotion of sleep in adults in the intensive care unit.cited 56× |
| melatonin | Decreases - as effective as midazolam in reducing | children's anxiety | Human | children | 0.5 mg/kg (max 20 mg), single oral dose. | Premedication with melatonin vs midazolam: efficacy on anxiety and compliance in paediatric surgical patients.cited 29× |
| oral melatonin premedication | Decreases - reducing | preoperative anxiety | Human | children undergoing elective surgery | 0.5 mg/kg (max 20 mg), single oral dose. | Premedication with melatonin vs midazolam: efficacy on anxiety and compliance in paediatric surgical patients.cited 29× |
| oral melatonin premedication | No effect - did not show significant differences | preoperative anxiety levels | Human | children premedicated with melatonin and midazolam | 0.5 mg/kg (max 20 mg), single oral dose. | Premedication with melatonin vs midazolam: efficacy on anxiety and compliance in paediatric surgical patients.cited 29× |
| melatonin | Decreases - may reduce | delayed postoperative anxiety measured six hours after surgery using the State-Trait Anxiety Inventory (STAI) | Human | adults | Not specified in the abstract. | Melatonin for preoperative and postoperative anxiety in adults.cited 53× |
| melatonin | No effect - may be little or no difference in | immediate postoperative anxiety | Human | adults | Not specified in the abstract. | Melatonin for preoperative and postoperative anxiety in adults.cited 53× |
| melatonin | Decreases - may reduce | immediate postoperative anxiety measured on a 0 to 100 mm VAS | Human | adults | Not specified in the abstract. | Melatonin for preoperative and postoperative anxiety in adults.cited 53× |
| melatonin | Decreases - probably results in a reduction in | preoperative anxiety measured by a visual analogue scale (VAS, 0 to 100 mm) | Human | adults | Not specified in the abstract. | Melatonin for preoperative and postoperative anxiety in adults.cited 53× |
| melatonin | No effect - probably results in little or no difference in | preoperative anxiety measured on a 0 to 100 mm VAS | Human | adults | Not specified in the abstract. | Melatonin for preoperative and postoperative anxiety in adults.cited 53× |
| melatonin | No effect - helps to manage | dental anxiety | Human | — | Not specified | Melatonin: The potential avenues in dentistry. |
| melatonin (5 mg) | No effect - no statistically significant between-group differences | Generalized Anxiety Disorder Scale (GAD-7) | Human | males 18 years of age and older in recovery from substance use | 5 mg melatonin daily. | The Effect of Melatonin Upon Postacute Withdrawal Among Males in a Residential Treatment Program (M-PAWS): A Randomized, Double-blind, Placebo-controlled Trial.cited 3× |
| melatonin | No effect - was examined | perinatal anxiety | Human | women | Not specified | Perinatal anxiety: approach to diagnosis and management in the obstetric setting.cited 19× |
| melatonin | Decreases - could be used as an adjuvant treatment | peri-surgical anxiety | Human | patients during acute phases | 0.125mg (small dose mentioned for chronobiotic action; dose-effect relationship noted for sleep-inducing effects). | The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS).cited 35× |
| melatonin | No effect - did not find any evidence of a difference | postoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | Decreases - showed a reduction | postoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | No effect - did not find any evidence of a difference | postoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | Decreases - showed a reduction | preoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | No effect - did not show any difference | preoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | No effect - found no evidence of a difference | preoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | Decreases - can reduce | preoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | Decreases - may be equally as effective | preoperative anxiety | Human | adults | Not specified | Melatonin for pre- and postoperative anxiety in adults.cited 60× |
| melatonin | Decreases - had lower HADS | postoperative anxiety | Human | patients aged 40-60 years old with American Society of Anesthesiologists physical status I-II undergoing laminectomy | — | Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial.cited 6× |
| melatonin (MLT) | Decreases - significant | pre-operative anxiety | Human | — | Not specified | Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action.cited 55× |
| melatonin | No effect - did not reduce | preoperative anxiety | Human | patients undergoing hernia repair | — | Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. |
| melatonin | Decreases - effective in improving | sleep anxiety | Human | healthy children suffering from insomnia | — | The effect of treatment with melatonin on primary school aged children with difficulty in initiation and maintenance of sleep.cited 2× |
| melatonin use | Decreases - significantly improved | menopausal anxiety | Human | postmenopausal women | Not specified | Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.cited 2× |
| paediatric prolonged-release melatonin (PedPRM) | Decreases - positive effects | anxiety and depressive symptomatology | Human | children with autism spectrum disorders | Not specified in the abstract. | Protocol MelatoSom-Kids-PTSD: sleep disturbances in children and adolescents with post-traumatic stress disorder (PTSD) - a randomized double-blind placebo-controlled trial to investigate the efficacy of paediatric prolonged-release melatonin. |
| melatonin premedication | Decreases - was less effective than midazolam | preoperative anxiety | Human | anxious children awaiting day case elective surgery under general anaesthesia | 0.5 mg/kg | The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia.cited 2× |
| melatonin premedication | Decreases - was inferior to midazolam | preoperative anxiety | Human | anxious children awaiting day case elective surgery under general anaesthesia | 0.5 mg/kg | The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia.cited 2× |
| melatonin analogs | No effect - support the efficacy | generalized anxiety disorder (GAD) | Human | — | Not specified | Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review.cited 120× |
| 3 mg oral melatonin treatment daily | Decreases - exhibited a significantly lower score | Hamilton anxiety scale (HAMA) | Human | healthy perimenopausal women | 3 mg oral melatonin daily. | Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.cited 1× |
| oral melatonin | Decreases - showed sufficient anxiolytic effect | anxiety | Human | patients undergoing third molar surgery | 0.4 mg/kg (single oral dose). | Should Melatonin Be Used as an Alternative Sedative and Anxiolytic Agent in Mandibular Third Molar Surgery?cited 3× |
| oral melatonin 0.4 mg/kg | Decreases - decreased significantly | anxiety | Human | patients undergoing third molar surgery | 0.4 mg/kg (single oral dose). | Should Melatonin Be Used as an Alternative Sedative and Anxiolytic Agent in Mandibular Third Molar Surgery?cited 3× |
| Oral melatonin (10 mg) | No effect - showed no significant difference regarding | occurrence of anxiety | Human | critically ill patients | 10 mg orally per night. | The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial.cited 53× |
| NL plus melatonin (NLM) | Decreases - improved | anxiety level | Human | healthy subjects | 1 mg oral melatonin administered at 21:00. | Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?cited 62× |
| fluoxetine (20 mg in the morning) and melatonin (5 mg in the evening) | Decreases - comparable and statistically significant reduction | level of anxiety and depression | Human | overweight postmenopausal women, aged 54 - 65 years, with increased appetite | 5 mg melatonin in the evening, daily. | Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women.cited 38× |
| melatonin supplementation | Decreases - decreased | anxiety on the Hospital Anxiety Depression Scale | Human | patients with traumatic brain injury (TBI) | 2 mg prolonged-release melatonin (Circadin®) nightly, 2 hours before bedtime. | Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial.cited 88× |
| melatonin supplementation | Decreases - significantly reduced | Beck Anxiety Inventory (BAI) | Human | patients with PD | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Melatonin supplementation and the effects on clinical and metabolic status in Parkinson's disease: A randomized, double-blind, placebo-controlled trial.cited 53× |
| melatonin supplementation | Decreases - significantly decreased | Beck Anxiety Inventory index | Human | patients under methadone maintenance treatment (MMT) | — | The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.cited 35× |
| melatonin supplementation | Decreases - significantly decreased | Beck Anxiety Inventory index | Human | women with polycystic ovary syndrome (PCOS) | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.cited 58× |
| melatonin supplementation | Decreases - significantly decreased | Beck Anxiety Inventory index | Human | diabetic hemodialysis (HD) patients | 2 x 5mg/day (10mg total daily dose), taken 1 hour before bedtime. | The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.cited 39× |
| exogenous oral melatonin | Decreases - showed a significant improvement | scores of Hamilton Anxiety Rating Scale (HARS) | Human | HD patients | — | Study of Exogenous Melatonin as a Treatment Modality for Sleep and Psychiatric Disorders in Hemodialysis Patients.cited 3× |
| perioperative melatonin | Decreases - demonstrated significant analgesic and anxiolytic effects | pain and anxiety | Human | surgical patients | Not specified in the abstract. | The analgesic effects of exogenous melatonin in humans.cited 13× |
| 3 mg melatonin | No effect - differences | anxiety symptoms | Human | adult participants, aged 50 and older, undergoing elective or semi-elective cardiac surgery | 3 mg melatonin administered daily. | The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial.cited 10× |
| genetic deletion of melatonin receptors | No effect - found | No behavioral changes in anxiety levels | Animal | melatonin receptor-deficient mice | — | Genetic deletion of MT₁/MT₂ melatonin receptors enhances murine cognitive and motor performance. |
| oral melatonin premedication | Decreases - significantly reduced | anxiety | Human | children having blood samples taken | 0.5 mg/kg body weight (maximum 5 mg), administered orally 30 minutes before the procedure. | POTENTIAL USE OF MELATONIN IN PROCEDURAL ANXIETY AND PAIN IN CHILDREN UNDERGOING BLOOD WITHDRAWAL.cited 25× |