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1
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Evidence suggests MDMA mayincreaseMood.
5 studies (4 claims)
Emerging evidence
Typical effective dose 125 (125–125) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| MDMA-assisted psychotherapy | Increases - reported significantly more episodes | low mood | Human | participants | 75 mg, 100 mg, and 125 mg of MDMA with psychotherapy. | A comparison of MDMA-assisted psychotherapy to non-assisted psychotherapy in treatment-resistant PTSD: A systematic review and meta-analysis.cited 18× |
| 125 mg of MDMA | Increases - increased | positive mood | Human | healthy subjects | 125 mg MDMA | Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination.cited 99× |
| MDMA | Increases - included | low mood | Human | patients | Not specified | Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review.cited 92× |
| MDMA | No effect - mediated via | mood-altering effects | Human | — | Not specified | The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns. |