2
1
↑2
↓1
—0
Evidence suggests MDMA mayincreaseEfficacy.
3 studies (3 claims)
Emerging evidence
Typical effective dose 125 (125–125) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| MDMA-assisted psychotherapy | Increases - constitutes a substantial improvement | safety and efficacy | Human | — | Administered in up to three monthly 8-hour sessions (specific dosage not mentioned). | Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline.cited 5× |
| MDMA | Decreases - displayed | loss of efficacy | Human | — | Not specified | Human psychobiology of MDMA or 'Ecstasy': an overview of 25 years of empirical research.cited 112× |
| three MDMA sessions | Increases - more effective than two | treatment efficacy | Human | patients with treatment-resistant PTSD | Low-dose (25 mg plus 12.5 mg supplemental) or full-dose (125 mg plus 62.5 mg supplemental) MDMA administered during three experimental sessions. | A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).cited 226× |