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Evidence suggests MDMA mayincreaseBlood pressure.
5 studies (5 claims)
Emerging evidence
Typical effective dose 125 (63.25–176.5) mgacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| mdma | Increases - increased | blood pressure | Human | human body | Not specified | Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms.cited 11× |
| mda | Increases - induced robust increases | blood pressure | Human | participants | 1.5 mg/kg oral racemic MDMA (comparison dose). | Effects of the Psychedelic Amphetamine MDA (3,4-Methylenedioxyamphetamine) in Healthy Volunteers.cited 11× |
| mdai | Increases - increased blood pressure similar to 125 mg MDMA | blood pressure | Human | six healthy volunteers (four males, two females) | MDMA doses of 75 mg and 125 mg were compared to MDAI (3.0 mg/kg, range 180-228 mg). | Acute psychotropic, autonomic, and endocrine effects of 5,6-methylenedioxy-2-aminoindane (MDAI) compared with 3,4-methylenedioxymethamphetamine (MDMA) in human volunteers: A self-administration study. |
| clonidine | Decreases - lowered | blood pressure | Human | 16 healthy subjects | 125 mg p.o. MDMA, 150 μg p.o. clonidine | Effects of the α₂-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers.cited 55× |