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Evidence suggests Ketogenic Diet maydecreaseToxicity.
15 studies (14 claims)
Moderate consensus
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| lysine restricted diet | Decreases - might address | potential toxicity of accumulating αAASA, P6C and pipecolic acid | Human | patients with PDE (pyridoxine dependent epilepsy) | Pyridoxine-HCl: 100 mg IV or 30 mg/kg/day orally/enterally; long-term: 15-30 mg/kg/day (infants), up to 200 mg/day (neonates), 500 mg/day (adults); PLP: up to 30 mg/kg/day. | Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.cited 198× |
| restricted protein diet associated with L-carnitine (LC) supplementation | Decreases - decrease | accumulation of the major metabolites and therefore their toxicity | Human | patients affected by these disorders | — | Evidence That Long-Term Treatment Prevents Tissue Oxidative Damage in Patients With Inherited Disorders of the Propionate Pathway. |
| Adding plentiful vegetables and fruits to our diet | Decreases - can combat | heavy metal toxicity-related illness | Human | — | Not specified | Metal toxicity and natural antidotes: prevention is better than cure.cited 20× |
| Total replacement of diet with elemental formula | Decreases - could be effective | severe toxicity | Human | patients undergoing pelvic radiotherapy | Not specified | Nutritional strategies to prevent gastrointestinal toxicity during pelvic radiotherapy.cited 17× |
| supplementation of KGM into a low-fibre diet | Decreases - may contribute to the reduced | toxicity of faecal water and precancerous risk factors of human colon cancer | HumanAnimal | — | 4.5 g/d | Ameliorative effects of konjac glucomannan on human faecal β-glucuronidase activity, secondary bile acid levels and faecal water toxicity towards Caco-2 cells.cited 27× |
| an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants | Decreases - could decrease | the toxicity of antitumor drugs | HumanMolecular | — | Not available | Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review.cited 23× |
| plantain-based diet (PBD) | No effect - was able to protect and prevent | toxicity caused by ATZ | Animal | rat testes | 50%, 25%, and 12.5% PBD (preventive and therapeutic models). | Plantain-based diet decreases oxidative stress and inflammatory markers in the testes of rats exposed to atrazine.cited 3× |
| a prepared diet reduced to 50% of caloric needs for 48 h prior to each anthracycline treatment | Decreases - can reduce | anthracycline-related toxicity to the heart, aorta, and skeletal muscle | Human | women with early stage breast cancer scheduled to receive anthracycline treatment | Not specified for antioxidants (caloric restriction involved 50% of caloric needs for 48 hours prior to treatment). | Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer.cited 21× |
| concurrent intake of garlic, ginger and nutmeg at culinary dose in the diet | Decreases - has both therapeutic and prophylactic effect at mitigating Cd toxicity | Cd toxicity | Animal | cadmium exposed rats | 300 mg/kg body weight (spice mixture) | Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats.cited 4× |
| AKG diet supplementation in combination with ethanol | Decreases - protective effects | ethanol toxicity | HumanAnimal | D. melanogaster | 10-mM AKG | Alpha-ketoglutarate reduces ethanol toxicity in Drosophila melanogaster by enhancing alcohol dehydrogenase activity and antioxidant capacity.cited 13× |
| VCO-supplemented diet | Decreases - can ameliorate | SB-induced testicular toxicity | Animal | adult male rats | 5% and 15% VCO | Therapeutic potential of virgin coconut oil in mitigating sodium benzoate- model of male infertility: Role of Nrf2/Hmox-1/NF-kB signaling pathway.cited 5× |
| glutamine-enriched oligomeric diet (GEOD) | Decreases - had a protective effect in terms of the development of | gastrointestinal toxicity associated with chemotherapy and radiotherapy treatment | Human | patients with rectal cancer | 400 ml of GEOD or SPD daily. | Clinical, Functional, and Nutritional Efficacy of a Glutamine-Enriched Oligomeric Diet in Patients with Rectal Cancer.cited 5× |