Ketogenic Diet
→Epileptic seizures

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Evidence suggests Ketogenic Diet maydecreaseEpileptic seizures.

15 studies (18 claims)

Moderate consensus

Study Claims

16 of 20

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
lysine-restricted diet	No effect - used in a small proportion of patients with variable efficacy	seizures	Human	patients	1-55 mg/kg/day (pyridoxine)	Epilepsy Phenotypes of Vitamin B6-Dependent Diseases: An Updated Systematic Review.cited 14×
modified high amylopectin cornstarch (Glycosade) and low glycemic index diet	Decreases - improved	seizures and cognitive functions	Human	a new glucose transporter 1 deficiency syndrome patient	Modified high amylopectin cornstarch (Glycosade) at bedtime and low-glycemic-index diet with meals and snacks every 3-4 hours.	New Paradigm for the Treatment of Glucose Transporter 1 Deficiency Syndrome: Low Glycemic Index Diet and Modified High Amylopectin Cornstarch.cited 8×
fish oil (FO) diet during the lactation period	Decreases - significantly decreased	the number of tonic-clonic seizures	Animal	hypoxia groups	1 ml/day orally for 12 days.	Proinflammatory factors inhibition and fish oil treatment: A promising therapy for neonatal seizures.
low glycemic index diet	No effect - was not significantly different	mean frequency of seizures	Human	children with drug-refractory epilepsy	Not specified	Efficacy of low glycemic index diet therapy (LGIT) in children aged 2-8 years with drug-resistant epilepsy: A randomized controlled trial.cited 18×
low glycemic index diet (LGID)	Decreases - shows promise in reducing	seizures	Human	pediatric DRE	Not specified	The effects of low glycemic index diet on epileptic seizure frequency, oxidative stress, mental health, and health-related quality of life in children with drug-resistant epilepsy.
low glycemic index diet (LGID)	Decreases - induced a reduction of seizures severity	seizures severity	Animal	female SynIIKO mice	Not specified	Low glycemic index diet restrains epileptogenesis in a gender-specific fashion.cited 4×
Ketogenic diet (KD)	Decreases - reduces	ADD in generalized seizures	Animal	—	Not specified (high-fat, low-carbohydrate, adequate protein diet).	Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures.
Ketogenic diet (KD)	Increases - increased	duration of generalized seizures	Animal	rats	Not specified (high-fat, low-carbohydrate, adequate protein diet).	Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures.
Ketogenic diet (KD)	Increases - increased	latency of generalized seizures	Animal	rats	Not specified (high-fat, low-carbohydrate, adequate protein diet).	Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures.
Ketogenic diet (KD)	No effect - is an important therapy used in the control of	drug-refractory seizures	Human	—	Not specified	Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress.cited 14×
ketogenic diet	Decreases - reduced	number of seizures	Human	children with drug resistant epilepsy	Not specified	Potassium citrate and metabolic acidosis in children with epilepsy on the ketogenic diet: a prospective controlled study.cited 13×
ketogenic diet (KD)	Decreases - has been shown to be successful in controlling	seizures	Human	older children	Not specified	Ketogenic diet in the treatment of epilepsy in children under the age of 2 years: study protocol for a randomised controlled trial.cited 14×
ketogenic diet	Decreases - significant seizure reduction	seizures	Human	two-thirds	8 started with a ketogenic formula, 1 with a food-based diet (specific amounts not detailed).	The Ketogenic Diet: An Underrecognized Therapy for Rett Syndrome.
ketogenic diet	Decreases - has high efficacy	seizures associated with Rett syndrome	Human	—	8 started with a ketogenic formula, 1 with a food-based diet (specific amounts not detailed).	The Ketogenic Diet: An Underrecognized Therapy for Rett Syndrome.
low-protein diet with restricted arginine and increased ornithine	Decreases - results in improvement	epileptic seizures	Human	patients with GAMT deficiency	Not specified	Guanidinoacetate methyltransferase deficiency (GAMT).cited 21×
recurrent seizures plus normal diet (RS + ND)	Decreases - reduced latencies	myoclonic seizures induced by penicillin	Animal	Sprague-Dawley rats	—	Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.