Ketamine→Depression

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↓7

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Evidence suggests Ketamine maydecreaseDepression.

7 studies (7 claims)

Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.

5 of 7

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
ketamine	Decreases - reduction	depression	Human	patients with terminal illness	Not specified	Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review.cited 59×
ketamine	Decreases - beneficial therapeutic effects	depression	HumanMolecular	—	Not specified	Ketamine, benzoate, and sarcosine for treating depression.cited 9×
Ketamine	Decreases - produces rapid antidepressant effects	depression	Animal	patients with treatment-resistant depression	Not specified (intraperitoneal administration).	Antidepressant-like effects of tomatidine and tomatine, steroidal alkaloids from unripe tomatoes, via activation of mTORC1 in the medial prefrontal cortex in lipopolysaccharide-induced depression model mice.cited 1×
ketamine	Decreases - effective treatments	depression	Human	—	Not specified	Prediction of individual treatment allocation between electroconvulsive therapy or ketamine using the Personalized Advantage Index.
ketamine	Decreases - successful use	depression	Human	—	Not specified	Licit use of illicit drugs for treating depression: the pill and the process.

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Ketamine→Depression