3
5
2
↑3
↓5
—2
Evidence suggests Calcium maydecreaseOutcome.
11 studies (10 claims)
Emerging evidence
Typical effective dose 750 (625–875) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| calcium-containing replacement solution | No effect - had a similar | kidney outcome | Human | patients | 4% trisodium citrate solution infusion (mean ~170 mL/h in both groups). | Calcium-containing versus calcium-free replacement solution in regional citrate anticoagulation for continuous renal replacement therapy: a randomized controlled trial.cited 6× |
| calcium supplementation | Decreases - reduced | composite outcome maternal death or serious morbidity | Human | women | High-dose: ≥1 g/day; Low-dose: <1 g/day (some trials combined with vitamin D, linoleic acid, or antioxidants). | Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.cited 209× |
| calcium supplementation | Decreases - reduced | composite outcome maternal death or serious morbidity | Human | women | At least 1 g daily | Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.cited 178× |
| calcium supplementation | Increases - consequently improving | neonatal outcome | Human | — | — | Could molecular assessment of calcium metabolism be a useful tool to early screen patients at risk for pre-eclampsia complicated pregnancy? Proposal and rationale.cited 8× |
| calcium supplementation | Increases - to improve | pregnancy outcome | Human | patients with calcium metabolism disorders | — | Could molecular assessment of calcium metabolism be a useful tool to early screen patients at risk for pre-eclampsia complicated pregnancy? Proposal and rationale.cited 8× |
| calcium supplementation | Decreases - may reduce the risk of | women experiencing the composite outcome pre-eclampsia or pregnancy loss at any gestational age | Human | non-pregnant women with previous pre-eclampsia | 500 mg daily before conception until 20 weeks' gestation, then 1.5 g daily until birth. | Calcium supplementation commencing before or early in pregnancy, for preventing hypertensive disorders of pregnancy.cited 40× |
| routine oral calcium and vitamin D supplements | No effect - are beneficial | postoperative outcome | Human | patients after total thyroidectomy with central neck lymph node dissection | Not specified | Comparison of calcitriol versus cholecalciferol therapy in addition to oral calcium after total thyroidectomy with central neck lymph node dissection: a prospective randomized study.cited 13× |
| High-dose calcium supplementation (≥ 1 g/day) | Decreases - reduced | composite outcome maternal death or serious morbidity | Human | women | Low-dose calcium (< 1 g/day), with one trial combining calcium and antioxidants (specific dosage not detailed). | Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.cited 233× |
| calcium plus antioxidants and other supplements | Decreases - observed a reduction | the composite outcome pre-eclampsia and/or pregnancy loss at any gestational age | Human | — | 200 mg N-Acetylcysteine (alongside 800 mg calcium and other supplements), taken twice daily. | Calcium supplementation commencing before or early in pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy.cited 19× |
| calcium and vitamin D supplementation | Increases - higher proportion of patients achieving | good outcome [modified Rankin Scale score 0-2] at 6 months | Human | ischaemic stroke survivors with vitamin D deficiency/insufficiency | Not specified in the abstract. | Effect of Vitamin D and calcium supplementation on ischaemic stroke outcome: a randomised controlled open-label trial.cited 41× |
| calcium source and its surrounding matrix | No effect - will have an influence over the physiological outcome | physiological outcome | Human | — | Not specified | Role of calcium on lipid digestion and serum lipids: a review.cited 18× |
| Oral calcium | No effect - showed no difference | composite outcome (intensity and frequency) for partial improvement | Human | pregnant women | Not available | Interventions for leg cramps in pregnancy.cited 20× |