Caffeine
→Stress

2

6

5

↑2

↓6

—5

Evidence suggests Caffeine maydecreaseStress.

12 studies (13 claims)

Conflicting evidence

Typical effective dose 6 (6–7) mgacross 4 dosed studies

Study Claims

13 of 13

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
coffee consumption and caffeine supplementation	Decreases - reducing	oxidative stress	Human	—	—	Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism-A Concise Review.cited 1×
caffeine supplementation	No effect - had no effect on	biomarkers of oxidative stress	Human	12 healthy males	6 mg/kg, single dose 60 minutes before exercise.	Caffeine Does Not Alter Performance, Perceptual Responses, and Oxidative Stress After Short Sprint Interval Training.cited 1×
caffeine supplementation	No effect - does not decrease	oxidative stress	Human	—	6 mg/kg, single dose 60 minutes before exercise.	Caffeine Does Not Alter Performance, Perceptual Responses, and Oxidative Stress After Short Sprint Interval Training.cited 1×
caffeine supplementation	Decreases - decrease	oxidative stress	Human	trained young individuals	Not specified	THE EFFECT OF CAFFEINE SUPPLEMENTATION ON TRAINED INDIVIDUALS SUBJECTED TO MAXIMAL TREADMILL TEST.cited 7×
caffeine supplementation	Increases - induced higher increases in oxidative stress markers	oxidative stress markers	Human	athletes	6 mg/kg body weight, single dose before competition.	Effects of caffeine on the inflammatory response induced by a 15-km run competition.cited 40×
caffeine administration	Decreases - ameliorating	oxidative stress	Animal	rats	Not specified.	Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats.
a product containing bitter orange extract, caffeine and green tea extract	No effect - does not lead to increased	cardiovascular stress	Human	—	13 mg p-synephrine and 176 mg caffeine per capsule, taken with each of three meals.	Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans.cited 26×
chronic caffeine administration	No effect - prevented	stress and/or WD-induced impairment of spatial learning and memory	Animal	adult male Wistar rats	0.3 g/L in drinking water	Caffeine prevents cognitive impairment induced by chronic psychosocial stress and/or high fat-high carbohydrate diet.cited 43×
caffeine	Decreases - have antioxidant capacity	oxidative stress	Human	—	Not provided	Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin.cited 33×
caffeine	Decreases - protects against H/R-induced neuronal injury by regulating ACSL4-mediated ferroptosis, reducing	oxidative stress	Molecular	neuronal cells	Varying concentrations (specific amounts not provided).	Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study.
caffeine (10 mg/kg)	Decreases - showed favorable changes	oxidative stress and inflammatory biomarkers	Animal	Swiss male mice	10 mg/kg	Effect of cytidine-5'-diphosphocholine alone, caffeine or their combination on oxidative stress and inflammatory response in an experimentally-induced Parkinson's disease.
caffeine	Increases - induces hormetic dose responses	resilience to inflammatory stress	HumanMolecular	bone marrow stem cells (BMSCs)	Not specified	Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress.cited 20×
caffeine	No effect - no difference	thermal stress	Human	eight healthy, recreationally active males	6 mg/kg	Effect of a moderate caffeine dose on endurance cycle performance and thermoregulation during prolonged exercise in the heat.cited 25×