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6
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Evidence suggests Caffeine maydecreaseHeadache.
7 studies (9 claims)
Emerging evidence
Typical effective dose 400 (400–400) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| prophylactic caffeine supplementation | Decreases - mitigates | systemic hypercapnia and headache during graded CO2 exposure | Human | — | 400 mg caffeine (single dose). | Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial. |
| caffeine (400 mg) | Decreases - substantially reduced | headache during graded CO2 exposure | Human | 23 participants | 400 mg caffeine (single dose). | Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial. |
| caffeine supplementation | Decreases - has shown promise in preventing | caffeine withdrawal headache | Human | patients at risk of caffeine withdrawal, such as those placed on nil per os (NPO) status | — | Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.cited 5× |
| caffeine supplementation | Decreases - reduces the incidence | perioperative headache | Human | chronic caffeinators | — | Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps.cited 2× |
| caffeine and melatonin association with lithium or indomethacin | Decreases - seems to produce an additional therapeutic efficacy | hypnic headache | Human | — | Not specified | Focus on therapy of hypnic headache.cited 9× |
| caffeine | No effect - did not yield robust evidence to recommend their use as single preventive agents | hypnic headache prevention | Human | — | Not specified | Focus on therapy of hypnic headache.cited 9× |
| Caffeine withdrawal | Increases - triggering attacks of headache | headache | Human | — | Not available | Diet and Headache: Part 1.cited 61× |
| caffeine intake | Decreases - is common acute, as well as prophylactic, treatment | hypnic headache | Human | patients with hypnic headache | Not available | Hypnic headache.cited 5× |
| caffeine | No effect - appear unhelpful | post-lumbar puncture headache prevention | Human | — | — | Preventing Post-Lumbar Puncture Headache.cited 17× |