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Evidence suggests Caffeine mayincreaseAnxiety.
4 studies (3 claims)
Emerging evidence
Typical effective dose 20 (20–20) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| high caffeine intake | Increases - correlates with elevated | anxiety levels | Human | individuals predisposed to anxiety disorders | Not specified (dose-dependent effects noted). | Coffee and mental disorders: How caffeine affects anxiety and depression.cited 1× |
| a combination of caffeine and nicotine | Decreases - reduce | anxiety | Animal | male C57BL/6J mice | Caffeine (20 mg/kg) combined with nicotine (0.1 mg/kg). | The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice. |
| caffeine | No effect - modifies | anxiety | Human | athletes | — | Caffeine and Exercise: What Next?cited 92× |
| caffeine | Increases - may help improve | anxiety | Human | — | Not specified | Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review.cited 3× |