10
14
2
↑10
↓14
—2
Evidence suggests Alcohol maydecreaseLiver enzyme activity.
21 studies (26 claims)
Emerging evidence
Typical effective dose 100 (100–100) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| Inonotus obliquus water extraction and alcohol precipitation extracts (IO2) | Decreases - showed a significantly lower | half inhibitory concentration for DPPH scavenging activity | AnimalMolecular | — | Not specified | Effects of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Extracts on NOS-cGMP-PDE5 Pathway in Rat Penile Smooth Muscle Cells.cited 4× |
| moderate alcohol consumption | Increases - appear to increase | PON1 activity | Human | — | Not specified | Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.cited 139× |
| cinnamyl alcohol | Decreases - significantly inhibited | Tph1 transcription activity | AnimalMolecular | in vitro | Not specified | Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats.cited 8× |
| XL binding to polyvinyl alcohol (PVA) | Increases - enhances | XL photophysical activity | Molecular | — | Not specified | Pharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll α Derivative.cited 1× |
| oral administration of PF (100 mg/kg) alongside alcohol consumption | Decreases - significantly reduced | the activity of these enzymes | AnimalMolecular | mice | 100 mg/kg, administered orally alongside alcohol. | Psyllium fiber improves hangovers and inflammatory liver injury by inhibiting intestinal drinking.cited 1× |
| alcohol consumption | Increases - influenced | ALT activity | Human | — | Not available | Alanine aminotransferase-old biomarker and new concept: a review.cited 158× |
| alcohol extract from the aerial part of dill (DE) | Decreases - significantly reduces | disease activity index (DAI) | AnimalMolecular | DSS-induced UC mice | 200 mg/kg (low dose) and 400 mg/kg (high dose) administered daily by gavage. | Exploring the promising potential of alcohol extract from the aerial part of dill in ameliorating DSS-induced ulcerative colitis in mice. |
| alcohol | Increases - increased | activity of aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) | Animal | rats | Not specified | Therapeutic role of Cuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicity.cited 23× |
| alcohol | Increases - increased significantly | activity of phospholipase A and C in the liver | Animal | rats | Not specified | Therapeutic role of Cuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicity.cited 23× |
| alcohol | Decreases - inhibits | tricarboxylic acid cycle activity | Animal | — | Thermally oxidized sunflower oil (15%), alcohol (20%), NAC (150 mg/kg body weight) | Changes in Activities of MMP in Alcohol and Thermally Oxidized Sunflower Oil-Induced Liver Damage: NAC Antioxidant Therapy.cited 9× |
| mu-opioid receptor (MOR) regulation of alcohol-induced dopamine release | Decreases - females may be less dependent on MOR activity at lower doses of alcohol relative to higher doses | MOR activity dependence | Human | females | Not specified (varied across included studies). | Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. |
| alcohol exposure | Decreases - significantly decreased | osteoblastic activity | Animal | male Sprague-Dawley rats | Not specified (oral administration of palm vitamin E and alpha-tocopherol). | Vitamin E Improves Cellular and Structural Bone Histomorphometry in an Alcohol-Induced Osteoporosis Rat Model.cited 1× |
| Perillyl alcohol | Decreases - significantly decreased the increase in | acetylcholinesterase activity | Animal | Rats that received streptozotocin infusion | 25, 50, and 100 mg/kg administered orally (p.o.) | Neuroprotective effect of Perillyl alcohol in sporadic Alzheimer's disease in rats. |
| perillyl alcohol (POH) | Decreases - attenuated | telomerase activity | Molecular | rb4E cells | — | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. |
| perillyl alcohol (POH) | No effect - regulate | telomerase activity | Molecular | cancer cell lines with elevated eIF4E | — | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. |
| perillyl alcohol (POH) | No effect - unaffected | telomerase activity | Molecular | control cells | — | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. |
| Glycyrrhizic acid (GA) and patchouli alcohol (PA) | Decreases - inhibit | 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity | Animal | — | — | Glycyrrhizic acid and patchouli alcohol in Huoxiang Zhengqi attenuate intestinal inflammation and barrier injury via regulating endogenous corticosterone metabolism mediated by 11β-HSD1.cited 3× |
| hot acid-alcohol treatment | Increases - increased | cellular antioxidant activity | Molecular | — | Not specified | Conversion of condensed tannin from chokeberry to cyanidin: Evaluation of antioxidant activity and gut microbiota regulation.cited 2× |
| hot acid-alcohol treatment | Increases - increased | total antioxidant activity | Molecular | — | Not specified | Conversion of condensed tannin from chokeberry to cyanidin: Evaluation of antioxidant activity and gut microbiota regulation.cited 2× |
| patchouli alcohol (PA) | Increases - superior to that of amoxicillin | antibacterial activity | Molecular | Helicobacter pylori | — | Selective antibacterial activity of patchouli alcohol against Helicobacter pylori based on inhibition of urease.cited 27× |
| patchouli alcohol (PA) | Decreases - significantly reduced | disease activity index (DAI) | Animal | DSS-induced mice | — | Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism.cited 80× |
| patchouli alcohol | Decreases - could inhibit | H. pylori urease activity | Molecular | H. pylori | — | [Mechanism of anti-Helicobacter pylori urease activity of patchouli alcohol].cited 3× |
| patchouli alcohol | Decreases - was obviously decreased | urease activity | Molecular | H. pylori | — | [Mechanism of anti-Helicobacter pylori urease activity of patchouli alcohol].cited 3× |
| patchouli alcohol (PA) | Decreases - inhibited | intracellular H. pylori urease activity | Molecular | H. pylori | — | Effect of patchouli alcohol on macrophage mediated Helicobacter pylori digestion based on intracellular urease inhibition.cited 17× |
| patchouli alcohol (PA) | No effect - did not inhibit | isolated urease activity | Molecular | H. pylori | — | Effect of patchouli alcohol on macrophage mediated Helicobacter pylori digestion based on intracellular urease inhibition.cited 17× |
| Patchouli alcohol (PA) | Increases - pre-biotic-like | pre-biotic activity | Human | — | — | Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review.cited 32× |