Alcohol
→ALT

5

1

1

↑5

↓1

—1

Evidence suggests Alcohol mayincreaseALT.

7 studies (7 claims)

Emerging evidence

Study Claims

7 of 7

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
alcohol consumption	Increases - influenced	ALT activity	Human	—	Not available	Alanine aminotransferase-old biomarker and new concept: a review.cited 158×
Alcohol consumption	No effect - had no significant effect on	serum ALT levels	Human	DM patients	Not specified	Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus.cited 19×
heavy alcohol consumption	Increases - showed close association with	elevated ALT and aspartate aminotransferase (AST)	Human	alcohol-dependent (AD) patients without clinical manifestations of liver injury	Not specified	Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.cited 31×
alcohol administered orally	Increases - leads to swift alterations	blood ALT levels	Animal	male pet rabbits	Not specified	VITAMIN E SHIELDS AGAINST ALCOHOLIC TOXICITY BY SAFEGUARDING HEPATIC PARENCHYMAL MORPHOLOGY AND LOWERING BLOOD ALT LEVELS.
alcohol + heated sunflower oil (ΔPUFA)	Increases - increase in the activities	AST and ALT	Animal	Male albino rats of Wistar strain	Not specified.	Protective effect of Phyllanthus niruri on alcohol and heated sunflower oil induced hyperlipidemia in Wistar rats.cited 8×
at risk alcohol use	Increases - associated with	occurrence of an ALT flare	Human	—	Not specified	Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection.cited 26×
Patchouli alcohol (PA)	Decreases - decreased the elevation of	ALT and AST levels	Animal	male Wistar rats	—	Patchouli alcohol ameliorates acute liver injury via inhibiting oxidative stress and gut-origin LPS leakage in rats.cited 22×