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Effect of Heartfulness Meditation on Stress Biomarkers, Burnout and Well-Being: A Randomized Controlled Study.

Stress and health : journal of the International Society for the Investigation of Stress
April 1, 2025
Mansee Thakur et al. (4 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to evaluate the effect of Heartfulness meditation on stress biomarkers, burnout, and well-being in individuals experiencing moderate to high perceived stress.

Results Summary

The study found that Heartfulness meditation significantly increased serum nitrate/nitrite levels, professional efficacy, and well-being, while significantly decreasing exhaustion, cynicism, and cortisol levels compared to the control group. A negative correlation was observed between serum MDA and well-being, and a positive correlation between MDA and cortisol.

Population

100 participants aged 18-24 years with moderate to high perceived stress.

Effective Dosage

Daily Heartfulness meditation (specific duration per session not specified).

Duration

12 weeks.

Interactions

None mentioned.

Extracted Claims (8)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Heartfulness meditation
increase
serum nitrate/nitrite levels
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant increase
#1
Heartfulness meditation
increase
professional efficacy
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant increase
#2
Heartfulness meditation
increase
well-being
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant increase
#3
Heartfulness meditation
decrease
exhaustion
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant decrease
#4
Heartfulness meditation
decrease
cynicism
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant decrease
#5
Heartfulness meditation
decrease
cortisol levels
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant decrease
#6
-
decrease
serum MDA and well-being
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
significant negative correlation
#7
-
increase
MDA and cortisol
participants aged between 18 and 24 years experiencing moderate to high perceived stress
-
positive correlation
#8
Abstract

The rise in mental health conditions and stress has attracted global attention. Non-pharmacological and traditional approaches like meditative practices are showing promising results. Therefore, the aim of the study was to evaluate the effect of Heartfulness meditation on stress biomarkers, burnout, and well-being. A double-arm prospective randomized controlled study was carried out on 100 participants aged between 18 and 24 years, experiencing moderate to high perceived stress as assessed by the Perceived Stress Scale (PSS-10). These participants were randomized into a study group (meditation) and control group (sham meditation). An intervention of Heartfulness meditation was carried out daily for 12 weeks. Psychometric analysis was carried out to study burnout (exhaustion, cynicism and professional efficacy) and well-being using the standard validated questionnaires- Maslach Burnout Inventory (MBI) and WHO-Well-being Index (WHO-WBI). Biochemical analysis was also carried out to study psychological stress (serum cortisol), and oxidative stress (serum nitrate/nitrite and serum malondialdehyde (MDA) at baseline and post-intervention. Statistical analysis was carried out using the IBM SPSS software version 26.0. p values < 0.05 were considered statistically significant. A significant increase in serum nitrate/nitrite levels, professional efficacy, and well-being, and a significant decrease in measures such as exhaustion, cynicism, and cortisol levels were observed in the study group than the control group post-intervention. A significant negative correlation was also observed between serum MDA and well-being, whereas a positive correlation was observed between MDA and cortisol. The findings from this research suggest the role of Heartfulness meditation in reducing stress and burnout along with improving the well-being of an individual. Therefore, Heartfulness meditation can be used as a potential tool to improve mental health and well-being. However, future studies with a larger number of samples are needed to strengthen our findings. Trial Registration: Clinical Trial Registry of India: CTRI/2023/10/058,423 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=ODIyOTA=&Enc=&userName=CTRI/2023/10/058423).

Medical Subject Headings (MeSH)
HumansMeditationMaleFemaleBiomarkersYoung AdultStress, PsychologicalAdolescentHydrocortisoneAdultBurnout, ProfessionalOxidative StressMalondialdehydeProspective StudiesNitratesNitrites
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality80/10
Research Impact Scores
APT Score0.05
Weight Score2.60
Normalized Score0.70
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Effect of Heartfulness Meditation on Stress Biomarkers, Burn... | Panacea Index