High-intensity resistance training in patients with myositis - 1-year follow-up on a randomised controlled trial.
Study Goal
The researchers aimed to determine if improvements in quality of life, muscle strength, and endurance from high-intensity resistance training persisted one year after completing a 16-week intervention in patients with myositis.
Results Summary
The study found sustained improvements in muscle endurance at 1-year follow-up, with indications of lasting enhancements in quality of life and strength, and no increase in disease activity or damage. However, these improvements were not significantly different from the control group at follow-up.
Population
Patients with myositis (32 participants initially, 27 completed follow-up).
Effective Dosage
High-intensity resistance training (specific dosage not detailed in abstract).
Duration
16 weeks of intervention, with 1-year follow-up.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high-intensity resistance training | increase | quality of life | patients with myositis | - | improved | #1 |
high-intensity resistance training | increase | muscle strength | patients with myositis | - | improved | #2 |
high-intensity resistance training | increase | endurance | patients with myositis | - | improved | #3 |
16 weeks of high-intensity resistance training | increase | muscle endurance (FI3) | patients with myositis | mean change of 10.7 (CI95: 2.2;19.1) | remained at 1-year follow-up | #4 |
16 weeks of high-intensity resistance training | increase | QoL (SF36, physical component summary) | patients with myositis | 4.8 (CI95: 0.9;8.7) | sustained | #5 |
16 weeks of high-intensity resistance training | increase | muscle strength (MMT8) | patients with myositis | 1.8 (CI95: 0.8; 2.9) | sustained | #6 |
16 weeks of high-intensity resistance training | increase | functional capacity measures | patients with myositis | - | sustained | #7 |
16 weeks of high-intensity resistance training | no change | disease activity | patients with myositis | - | were similar | #8 |
16 weeks of high-intensity resistance training | no change | disease damage | patients with myositis | - | were similar | #9 |
16 weeks of high-intensity resistance training | increase | muscle endurance | patients with myositis | - | showed sustained improvements | #10 |
16 weeks of high-intensity resistance training | increase | quality of life | patients with myositis | - | lasting enhancements | #11 |
16 weeks of high-intensity resistance training | increase | strength | patients with myositis | - | lasting enhancements | #12 |
16 weeks of high-intensity resistance training | no change | disease activity | patients with myositis | - | no increase | #13 |
16 weeks of high-intensity resistance training | no change | disease damage | patients with myositis | - | no increase | #14 |
Reduced quality of life in patients with myositis is partly due to impairments in muscle strength, muscle endurance and functional capacity. In a recent randomised controlled trial (RCT) (NCT04486261) we showed that high-intensity resistance training improved quality of life, muscle strength, and endurance. This follow-up study aimed to investigate if these improvements remained persistent one year after completing 16 weeks of high-intensity resistance training. A total of 32 participants (intervention group (IG): 15; control group (CG): 17) were enrolled in the RCT, with 27 (IG: 13; CG: 14) completing the 1-year follow-up. Outcomes were assessed at three time points: baseline (weeks - 4 - 0), post-intervention (weeks 17-18), and 1-year follow-up (weeks 52-54). Outcomes included quality of life (QoL, SF36), functional capacity, muscle endurance (functional index 3 (FI3)), body composition (DEXA), and disease activity/damage, including manual muscle test 8 (MMT8). Training-induced improvements in muscle endurance (FI3) remained at 1-year follow-up, with a mean change of 10.7 (CI95: 2.2;19.1) in favour of IG (p = 0.01). Within-group improvements in IG were sustained for QoL (SF36, physical component summary) (4.8 (CI95: 0.9;8.7), p = 0.02), muscle strength (MMT8) (1.8 (CI95: 0.8; 2.9), p < 0.01), and functional capacity measures (p ≤ 0.04), although not significantly different from CG at 1-year follow-up. Disease activity and disease damage were similar between IG and CG at 1-year follow-up. Patients with myositis completing 16 weeks of high-intensity resistance training showed sustained improvements in muscle endurance at 1-year follow-up compared to controls. Indications of lasting enhancements in quality of life and strength were also present, with no increase in disease activity or damage. NCT04486261.