The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats.
Study Goal
The researchers aimed to investigate the potential geroprotective effects of resveratrol in ageing rats.
Results Summary
The study did not find conclusive evidence of geroprotective effects from resveratrol across the evaluated organs, though sex-dependent differences in response were observed.
Population
Ageing rats (starting at 3 months, followed until 1 or 2 years of age).
Effective Dosage
Not specified
Duration
Up to 21 months (from 3 months to 2 years of age)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
resveratrol and melatonin | no change | geroprotective effects | ageing rats | no conclusive evidence | did not provide conclusive evidence of geroprotective effects | #1 |
resveratrol and melatonin | neutral | response to treatment | ageing rats | - | observed sex-dependent differences in response | #2 |
BACKGROUND: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats. METHODS: The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys. RESULTS: Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment. CONCLUSIONS: Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.