Effects of modified Wendan Decoction combined with acupuncture on inflammatory factors and immune function in urticaria patients.
Study Goal
The researchers aimed to determine whether modified Wendan Decoction combined with acupuncture could reduce serum inflammatory markers and improve immune function in patients with urticaria.
Results Summary
The study found that the combination of modified Wendan Decoction and acupuncture significantly improved clinical efficacy, reduced symptom scores, and lowered inflammatory markers (IL-4, IL-10, IL-25, IL-33, IFN-γ) compared to the control group treated with levocetirizine tablets. The observation group also had a lower recurrence rate, though the study did not address potential adverse effects or long-term safety.
Population
150 urticaria patients (specific demographics not detailed) admitted to the hospital, divided into an observation group (n=75) and a control group (n=75).
Effective Dosage
Not specified for acupuncture; modified Wendan Decoction dosage not detailed.
Duration
Not explicitly stated in the abstract.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
modified Wendan Decoction combined with acupuncture | increase | clinical efficacy | patients suffering from urticaria | - | demonstrated a higher clinical efficacy | #1 |
modified Wendan Decoction combined with acupuncture | decrease | symptom scores | patients suffering from urticaria | - | reductions in symptom scores | #2 |
modified Wendan Decoction combined with acupuncture | decrease | symptom scores | patients suffering from urticaria | - | showed significantly lower symptom scores | #3 |
modified Wendan Decoction combined with acupuncture | decrease | IL-4, IL-10, IL-25, IL-33, and IFN-γ | patients suffering from urticaria | - | levels decreased | #4 |
modified Wendan Decoction combined with acupuncture | decrease | IL-4, IL-10, IL-25, IL-33, and IFN-γ | patients suffering from urticaria | - | exhibited lower levels | #5 |
modified Wendan Decoction combined with acupuncture | decrease | recurrence rate | patients suffering from urticaria | - | recurrence rate was notably lower | #6 |
modified Wendan Decoction combined with acupuncture | decrease | serum inflammatory markers | patients with urticaria | - | effectively reduces serum inflammatory markers | #7 |
modified Wendan Decoction combined with acupuncture | increase | immune function | patients with urticaria | - | enhances immune function | #8 |
This study aimed to explore the effects of modified Wendan Decoction combined with acupuncture on serum inflammatory markers and immune function in patients suffering from urticaria. A total of 150 urticaria patients admitted to our hospital were randomly assigned to two groups: the observation group (n = 75) and the control group (n = 75). The control group received levocetirizine tablets, while the observation group was treated with modified Wendan Decoction along with acupuncture. Following treatment, the observation group demonstrated a higher clinical efficacy compared to the control group, with a statistically significant difference (P < 0.05). Both groups experienced reductions in symptom scores, including erythema, burning sensation, pruritus, wheals, fever accompanied by epigastric pain, nausea and vomiting, fatigue, and poor appetite. However, the observation group showed significantly lower symptom scores than the control group (P < 0.05). Additionally, levels of IL-4, IL-10, IL-25, IL-33, and IFN-γ decreased in both groups after treatment, but the observation group exhibited lower levels than the control group, again with a statistically significant difference (P < 0.05). The recurrence rate was notably lower in the observation group compared to the control group (P < 0.05). The combination of modified Wendan Decoction and acupuncture effectively reduces serum inflammatory markers and enhances immune function in patients with urticaria. This treatment demonstrates significant clinical effectiveness and holds potential for broader application in clinical settings.