Efficacy of probiotics combined with metformin and a calorie-restricted diet in obese patients with polycystic ovary syndrome.
Study Goal
To determine if adding probiotics to metformin and a calorie-restricted diet improves outcomes in obese PCOS patients compared to metformin and diet alone.
Results Summary
Probiotics combined with metformin and diet significantly improved hormone levels, insulin resistance, blood sugar, gut microbiota diversity, and BMI reduction compared to metformin and diet alone, though BMI reduction was similar between groups.
Population
Obese patients with polycystic ovary syndrome (PCOS) (n=141).
Effective Dosage
Not specified
Duration
June 2021 to December 2023 (retrospective analysis, exact intervention duration unclear)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
probiotics combined with metformin and a calorie-restricted diet | decrease | levels of endocrine hormone indicators | obese patients with polycystic ovary syndrome (PCOS) | - | significantly reduced | #1 |
probiotics combined with metformin and a calorie-restricted diet | decrease | Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) | obese patients with polycystic ovary syndrome (PCOS) | - | significantly reduced | #2 |
probiotics combined with metformin and a calorie-restricted diet | decrease | Fasting blood glucose (FPG) | obese patients with polycystic ovary syndrome (PCOS) | - | significantly reduced | #3 |
probiotics combined with metformin and a calorie-restricted diet | increase | Abundance of gut microbiota | obese patients with polycystic ovary syndrome (PCOS) | - | significantly increased | #4 |
probiotics combined with metformin and a calorie-restricted diet | increase | Shannon Wiener diversity index | obese patients with polycystic ovary syndrome (PCOS) | - | significantly increased | #5 |
probiotics combined with metformin and a calorie-restricted diet | decrease | body mass index (BMI) | obese patients with polycystic ovary syndrome (PCOS) | - | significant reduction | #6 |
metformin and a calorie-restricted diet | decrease | levels of endocrine hormone indicators | obese patients with polycystic ovary syndrome (PCOS) | - | significantly reduced | #7 |
metformin and a calorie-restricted diet | decrease | Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) | obese patients with polycystic ovary syndrome (PCOS) | - | significantly reduced | #8 |
metformin and a calorie-restricted diet | decrease | Fasting blood glucose (FPG) | obese patients with polycystic ovary syndrome (PCOS) | - | significantly reduced | #9 |
metformin and a calorie-restricted diet | increase | Abundance of gut microbiota | obese patients with polycystic ovary syndrome (PCOS) | - | significantly increased | #10 |
metformin and a calorie-restricted diet | increase | Shannon Wiener diversity index | obese patients with polycystic ovary syndrome (PCOS) | - | significantly increased | #11 |
metformin and a calorie-restricted diet | decrease | body mass index (BMI) | obese patients with polycystic ovary syndrome (PCOS) | - | significant reduction | #12 |
OBJECTIVE: To explore the efficacy of probiotics combined with metformin and a calorie-restricted diet in obese patients with polycystic ovary syndrome (PCOS). METHODS: Clinical data of 141 obese PCOS patients treated in the 73rd Group Army Hospital from June 2021 to December 2023 were retrospectively analyzed. Patients were grouped according to the treatment records: metformin group (n=69), patients treated with metformin and a calorie-restricted diet) and combined group (n=72, patients treated with probiotics combined with metformin and a calorie-restricted diet). Levels of endocrine hormone indicators, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), Fasting blood glucose (FPG), gut microbiota status, and Body mass index (BMI) were compared before and after the treatment in two groups. RESULTS: After the treatment, the levels of endocrine hormone indicators, HOMA-IR, and FPG in both groups were significantly reduced compared to pre-treatment levels and were significantly lower in the combined group compared to the metformin group (P<0.05). Abundance of gut microbiota and Shannon Wiener diversity index in both groups significantly increased after the treatment and were markedly higher in the combined group than in the metformin group (P<0.05). Treatment led to a significant reduction in the body mass index (BMI) in all patients (P<0.05). However, post-treatment BMI was comparable in the two groups (P>0.05). CONCLUSIONS: In obese patients with PCOS, adding probiotics to the metformin and calorie-restricted diet regimen is more effective in regulating hormone levels, improving blood sugar and insulin resistance, regulating gut microbiota status, and reducing BMI than metformin combined with calorie-restricted diet alone.