Effects of aerobic and resistance training on bone, muscle hypertrophy and inflammation in OVX mice.
Study Goal
The researchers aimed to compare the effects of resistance and aerobic training on bone quality, muscle area, and inflammatory markers in ovariectomized female mice.
Results Summary
Resistance training (climbing) improved bone quality and muscle area in ovariectomized mice, similar to aerobic training, but uniquely increased anti-inflammatory IL-10 levels. Both training modalities reduced body mass compared to sedentary controls.
Population
Ovariectomized (OVX) female c57bl/6 mice.
Effective Dosage
Not specified (protocol involved climbing for resistance training).
Duration
8 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
training | decrease | body mass | trained animals | p < 0.001 | reduced | #1 |
training | increase | bone quality | trained groups | - | was higher | #2 |
OVX | increase | TNF-α | OVX groups | - | increased | #3 |
training | no change | TNF-α | trained groups | - | did not alter | #4 |
climbing training | increase | IL-1β levels | climbing groups | - | were higher | #5 |
OVX | increase | IL-6 | OVX groups | p < 0.001 | increased | #6 |
aerobic training | increase | IL-6 | aerobic training groups | p < 0.001 | increased | #7 |
climbing training | increase | IL-10 | SHAM and climbing groups | p < 0.01 | was elevated | #8 |
training | increase | gastrocnemius muscle area | trained groups | p < 0.001 | increased | #9 |
aerobic and resistance training | increase | bone quality | OVX mice | - | improved | #10 |
aerobic and resistance training | increase | muscle area | OVX mice | - | improved | #11 |
climbing training | increase | IL-10 levels | trained groups | - | uniquely linked to increased | #12 |
OBJECTIVE: Bone loss is common with aging, particularly due to reduced sex hormones, as seen in menopause. While physical training is a known non-pharmacological therapy for osteopenia and sarcopenia, few studies compare resistance and aerobic protocols, especially with systemic inflammatory markers. This study evaluated the effects of aerobic and resistance training on physical performance, femoral trabecular bone quality (micro-computed tomography), serum inflammatory markers (IL-1β, IL-6, TNF-α, IL-10) and gastrocnemius muscle area in ovariectomized (OVX) female mice. METHOD: Sixty-four c57bl/6 mice were divided into OVX and SHAM groups and subjected to sedentary, resistance (climbing) or aerobic (treadmill) protocols for 8 weeks. RESULTS: Training reduced body mass (p < 0.001) in trained animals compared to sedentary. Bone quality was higher in trained groups versus sedentary. OVX increased TNF-α, but training did not alter it. IL-1β levels were higher in climbing than treadmill groups, and IL-6 increased with OVX and aerobic training (p < 0.001). IL-10 was elevated in the SHAM and climbing groups (p < 0.01). Gastrocnemius muscle area increased in both trained groups (p < 0.001) with no differences between modalities. CONCLUSION: Aerobic and resistance training improved bone quality and muscle area in OVX mice, with climbing training uniquely linked to increased IL-10 levels.