The effect of MIND diet on sleep status, mental health, and serum level of BDNF in overweight/obese diabetic women with insomnia: a randomized controlled trial.
Study Goal
The researchers aimed to examine the efficacy of the MIND diet on anthropometric measurements, sleep quality, depression, anxiety, and serum levels of cortisol and BDNF in type 2 diabetic women with insomnia.
Results Summary
The MIND diet significantly reduced waist circumference, improved sleep quality, depression, and anxiety, lowered cortisol levels, and increased BDNF compared to the control group.
Population
44 type 2 diabetic women with insomnia, aged 30 to 65 years.
Effective Dosage
Not specified (low-calorie MIND diet vs. low-calorie diet as control).
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
MIND low-calorie diet | decrease | waist circumference | type 2 diabetic women with insomnia | - | significant decrease | #1 |
MIND low-calorie diet | increase | sleep quality | type 2 diabetic women with insomnia | - | significant improvement | #2 |
MIND low-calorie diet | increase | depression | type 2 diabetic women with insomnia | - | significant improvement | #3 |
MIND low-calorie diet | increase | anxiety | type 2 diabetic women with insomnia | - | significant improvement | #4 |
MIND low-calorie diet | decrease | cortisol levels | type 2 diabetic women with insomnia | - | significant reduction | #5 |
MIND low-calorie diet | increase | BDNF | type 2 diabetic women with insomnia | - | significant increase | #6 |
Insomnia is common in type 2 diabetes mellitus (T2DM) and affects mental health and quality of life. The present study aimed to examine the efficacy of MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on the anthropometric measurements, sleep quality, depression, anxiety, and serum levels of cortisol and brain derived neurotrophic factor (BDNF) in type 2 diabetic women with insomnia. This randomized controlled trial (RCT) involved 44 type 2 diabetic women with insomnia, aged 30 to 65 years, who were randomly assigned to be under the MIND low-calorie diet (n = 22) or a low-calorie diet (LCD) as the control group (n = 22) for 12 weeks. The above-mentioned variables were assessed at the beginning and the end of intervention. Following the MIND diet for 12 weeks accompanied by the significant decrease of waist circumference and significant improvement of sleep quality, depression, and anxiety compared to the control group. In addition, the MIND diet vs. LCD group exhibited a significant reduction in the cortisol levels and a significant increase in BDNF. This study provides promising evidence of the effectiveness of the MIND diet in improving the sleep quality, mental health, and some related biochemical parameters in diabetic women with insomnia.Trial registration: IRCT20181111041611N8.