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Anti-glycaemic effect of the Chinese modified DASH diet combined with 23% low-sodium salt in patients with hypertension and type 2 diabetes: a clinical trial.

Diabetology & metabolic syndrome
February 12, 2025
Jiaxian An et al. (9 authors)
Journal ArticleHuman Study
Study Details

Study Goal

The researchers aimed to explore the anti-hyperglycaemic effect of the Chinese Modified DASH diet combined with 23% low-sodium salt and meal packs in patients with hypertension and type 2 diabetes.

Results Summary

The study found that the CM-DASH diet combined with low-sodium salt and meal packs reduced fasting and postprandial blood glucose levels, with Group C (meal packs) showing the most pronounced postprandial improvement. However, differences between groups were not statistically significant.

Population

Patients with hypertension and type 2 diabetes in China.

Effective Dosage

Not specified (meal packs and 23% low-sodium salt used).

Duration

8 weeks.

Interactions

None mentioned.

Extracted Claims (11)
InterventionDirectionEndpointPopulationDosageImpactClaim #
CM-DASH diet combined with 23% low-sodium salt and meal packs
decrease
glycemic control
patients with hypertension and type 2 diabetes
-
demonstrates potentially beneficial effects
#1
CM-DASH diet combined with 23% low-sodium salt and meal packs
decrease
salt intake
patients with hypertension and type 2 diabetes
-
reduces
#2
CM-DASH diet combined with 23% low-sodium salt and meal packs
increase
healthy eating habits
patients with hypertension and type 2 diabetes
-
fosters the development
#3
CM-DASH diet combined with 23% low-sodium salt and meal packs
decrease
patients' blood glucose
patients with hypertension and type 2 diabetes
-
contributing to the improvement
#4
Group A (control) dietary intervention
decrease
fasting blood glucose
participants with hypertension and type 2 diabetes
0.72 mmol/L
decreased
#5
Group B (23% low-sodium salt) dietary intervention
decrease
fasting blood glucose
participants with hypertension and type 2 diabetes
2.02 mmol/L
decreased
#6
Group C (meal packs) dietary intervention
decrease
fasting blood glucose
participants with hypertension and type 2 diabetes
2.06 mmol/L
decreased
#7
Group A (control) dietary intervention
decrease
postprandial blood glucose
participants with hypertension and type 2 diabetes
2.43 mmol/L
recorded reductions
#8
Group B (23% low-sodium salt) dietary intervention
decrease
postprandial blood glucose
participants with hypertension and type 2 diabetes
2.52 mmol/L
recorded reductions
#9
Group C (meal packs) dietary intervention
decrease
postprandial blood glucose
participants with hypertension and type 2 diabetes
4.29 mmol/L
recorded reductions
#10
Group C (meal packs) dietary intervention
increase
postprandial glucose control rate
participants with hypertension and type 2 diabetes
51.5%
demonstrated a 51.5% improvement
#11
Abstract

BACKGROUND: Although many previous trials have formalized the blood glucose-lowering effect of the DASH diet, relevant reports in China remain limited. This study aimed to explore the anti-hyperglycaemic effect of the Chinese Modified Dietary Approaches to Stop Hypertension diet combined with 23% low-sodium salt and meal packs in patients with hypertension and type 2 diabetes. METHODS: We conducted a randomized controlled single-blinded trial with a semi-open design; 100 participants were randomly assigned to Group A (control), Group B (23% low-sodium salt), and Group C (meal packs) for 8 weeks of dietary intervention. All participants were followed up weekly to collect glycaemia data (standardized meal tolerance test), salt use, and adverse events. RESULTS: Generalized estimating equation analysis indicated that fasting blood glucose decreased in all three groups following the intervention when compared to baseline. Group A decreased by 0.72 mmol/L (P = 0.008), while Groups B and C decreased by 2.02 mmol/L and 2.06 mmol/L, respectively (both P < 0.001). Although the latter two groups experienced greater reductions than Group A, the differences among the groups were not statistically significant (P = 0.450). For postprandial blood glucose, Group C showed the most pronounced decrease. The three groups recorded reductions of 2.43 mmol/L, 2.52 mmol/L, and 4.29 mmol/L, respectively (all P < 0.001), with again no significant difference observed between the groups (P = 0.088). The most notable enhancement in postprandial glucose was observed in Group C, which demonstrated a 51.5% improvement in its control rate. However, there was no statistically significant difference between the groups. No serious adverse events occurred during the trial. CONCLUSION: The CM-DASH diet combined with 23% low-sodium salt and meal packs demonstrates potentially beneficial effects on glycemic control in patients with hypertension and type 2 diabetes. This intervention reduces salt intake and fosters the development of healthy eating habits, thereby contributing to the improvement of patients' blood glucose. However, larger studies are necessary to confirm these findings. Trial registration ChiCTR2000029017. Registered January 11, 2020-Prospective registration, http://www.chictr.org.cn/.

Study Links
Quality Scores
Safety90
Efficacy75/10
Quality80/10
Research Impact Scores
APT Score0.05
Weight Score2.60
Normalized Score0.82
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