Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial.
Study Goal
The researchers aimed to determine whether combining time-restricted feeding (TRF) with a Lacto-Ovo-Vegetarian (LOV) diet improves metabolic markers, liver health, and weight loss in overweight and obese patients with Metabolic Associated Fatty Liver Disease (MAFLD).
Results Summary
The intervention group showed significant improvements in weight, BMI, waist circumference, liver enzymes (ALT, GGT), Fatty Liver Index, insulin levels, TNF-α, triglycerides, and HDL-C compared to the control group, suggesting that TRF with an LOV diet enhances metabolic and liver health in MAFLD patients.
Population
Overweight and obese patients with MAFLD (n=42 completed the study).
Effective Dosage
Time-restricted feeding (16/8 protocol) combined with a Lacto-Ovo-Vegetarian diet.
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | weight | overweight and obese patients with MAFLD | -8.07 ± 4.31 kg | showed significant reductions | #1 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | BMI | overweight and obese patients with MAFLD | -2.70 ± 1.32 kg/m2 | showed significant reductions | #2 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | waist circumference | overweight and obese patients with MAFLD | -8.00 ± 4.06 cm | showed significant reductions | #3 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | ALT | overweight and obese patients with MAFLD | -17.14 ± 14.33 U/L | showed significant reductions | #4 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | GGT | overweight and obese patients with MAFLD | -21.09 ± 24.06 U/L | showed significant reductions | #5 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | Fatty Liver Index | overweight and obese patients with MAFLD | -26.90 ± 15.81 | showed significant reductions | #6 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | insulin levels | overweight and obese patients with MAFLD | -3.89 ± 4.69 mU/L | showed significant reductions | #7 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | TNF-α | overweight and obese patients with MAFLD | -11.85 ± 12.52 pg/mL | showed significant reductions | #8 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | decrease | triglycerides | overweight and obese patients with MAFLD | -46.85 ± 54.55 mg/dL | improved with a reduction | #9 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | increase | HDL-C | overweight and obese patients with MAFLD | 3.91 ± 5.07 mg/dL | improved with an increase | #10 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | increase | metabolic markers | overweight and obese patients with MAFLD | - | enhances | #11 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | increase | liver health | overweight and obese patients with MAFLD | - | enhances | #12 |
time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet | increase | weight loss | overweight and obese patients with MAFLD | - | enhances | #13 |
Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight and obese patients with MAFLD. Forty-six participants were randomly assigned to either the intervention group (TRF with LOV diet) or the control group, with 21 participants completing the 12-week study in each group. The intervention group showed significant reductions in weight (-8.07 ± 4.31 kg), BMI (-2.70 ± 1.32 kg/m2), waist circumference (-8.00 ± 4.06 cm), as well as ALT (-17.14 ± 14.33 U/L), GGT (-21.09 ± 24.06 U/L), Fatty Liver Index (-26.90 ± 15.81), insulin levels (-3.89 ± 4.69 mU/L), and TNF-α (-11.85 ± 12.52 pg/mL) compared to the control group (all P < 0.05). Lipid profiles also improved with a reduction in triglycerides (-46.85 ± 54.55 mg/dL) and an increase in HDL-C (3.91 ± 5.07 mg/dL) in the intervention group compared to the control group (P < 0.05). These findings imply that TRF combined with a LOV diet enhances metabolic markers, liver health, and weight loss, thus potentially offering a practical dietary approach for managing MAFLD. Further long-term studies are necessary to validate these results and investigate their clinical applications.