The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials.
Study Goal
The researchers aimed to determine the effect of magnesium supplementation on serum levels of total cholesterol, triglycerides, LDL-C, and HDL-C in adults aged ≥18 years.
Results Summary
The study found no significant effect of magnesium on total cholesterol, triglycerides, or LDL-C levels but observed a significant increase in HDL-C levels. However, high heterogeneity suggests the need for further research.
Population
General population aged ≥18 years.
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium supplementation | no change | serum levels of total cholesterol (TC) | general population aged ≥ 18 years | weighted mean difference (WMD) = 0.34 mg/dl, 95% CI: -1.75 to 2.43, P = 0.749 | showed no significant differences | #1 |
magnesium supplementation | no change | serum levels of triglyceride (TG) | general population aged ≥ 18 years | weighted mean difference (WMD) = -2.06 mg/dl, 95% CI: -6.35 to 2.23, P = 0.346 | showed no significant differences | #2 |
magnesium supplementation | no change | serum levels of low density lipoprotein cholesterol (LDL-C) | general population aged ≥ 18 years | weighted mean difference (WMD) = 1.71 mg/dl, 95% CI: -0.81 to 4.24, P = 0.183 | showed no significant differences | #3 |
magnesium supplementation | increase | serum levels of high density lipoprotein cholesterol (HDL-C) | general population aged ≥ 18 years | weighted mean difference (WMD) = 1.21 mg/dl, 95% CI: 0.58 to 1.85, P < 0.001 | significantly increased | #4 |
BACKGROUND: Some evidence suggests magnesium might reduce serum levels of lipid profile. Due to the significance of this matter on hand, we centralized our aim to conduct a systematic review and meta-analysis to interrogate the effect of magnesium supplementation on serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) in the general population aged ≥ 18 years. METHODS: In line with conducting this study first, relevant articles were found through searching databases, including five databases: Cochrane Library, ClinicalTrials.gov, ISI Web of Science, Scopus, and PubMed until January 2024. Following fulfilling the first aim, their mean differences and standard deviations were calculated to conduct the meta-analysis. Ultimately, an assessment of the statistical heterogeneity of intervention effects was performed using I-squared statistics and Cochran's Q test. RESULTS: Regarding serum levels of TC, TG, LDL-C, and HDL-C, twenty-one, twenty-three, twenty, and twenty-five studies were included in the meta-analysis. The pooled estimates showed no significant differences in serum levels of TC, TG, and LDL-C between the magnesium group and comparison group (weighted mean difference (WMD) = 0.34 mg/dl, 95% confidence interval (CI): -1.75 to 2.43, P = 0.749, I2 = 99.1%; WMD=-2.06 mg/dl, 95% CI: -6.35 to 2.23, P = 0.346, I2 = 99.1; WMD = 1.71 mg/dl, 95% CI: -0.81 to 4.24, P = 0.183, I2 = 99.4, respectively). However, magnesium significantly increased HDL-C (WMD = 1.21 mg/dl, 95% CI: 0.58 to 1.85, P < 0.001, I2 = 99.5). CONCLUSION: In conclusion, our study showed that magnesium significantly increased HDL-C levels. However, due to high heterogeneity, we must note that more research is needed to make robust recommendations regarding magnesium supplementation in clinical practice. REGISTRY NUMBER: This study was registered in PROSPERO under the protocol number CRD42024505142.