Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination.
Study Goal
The researchers aimed to explore the anti-cancer efficacy of the ketogenic diet against glioblastoma (GBM) and its synergistic effects with oxyresveratrol and zinc.
Results Summary
The ketogenic diet demonstrated anti-cancer efficacy against C6-induced GBM cell lines, improved memory and motor coordination, and reduced tumor growth. It also synergized with oxyresveratrol and zinc to modify glucose and ketone levels, diminishing tumor burden.
Population
Wistar rats with C6-induced glioblastoma.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
ketogenic diet | decrease | C6-induced GBM cell lines | C6-induced GBM cell lines | - | has an anti-cancer efficacy | #1 |
ketogenic diet | decrease | GBM cell lines | GBM cell lines | - | exerts a synergistic effect with the epigenetic modulator, oxyresveratrol, and zinc | #2 |
treatment groups | increase | memory and motor coordination | - | - | improved | #3 |
treatment groups | neutral | glucose and ketone levels | - | - | modified | #4 |
treatment groups | decrease | tumor burden and Ki-67 proliferative index | - | - | reduced | #5 |
ketogenic diet along with its combination such as oxyresveratrol and zinc | decrease | C6-induced GBM | Wistar rats | - | revealed the therapeutic effect | #6 |
ketogenic diet along with its combination such as oxyresveratrol and zinc | increase | memory and motor coordination | Wistar rats | - | improved | #7 |
ketogenic diet along with its combination such as oxyresveratrol and zinc | decrease | tumor growth | Wistar rats | - | reduced | #8 |
ketogenic diet along with its combination such as oxyresveratrol and zinc | neutral | glucose and ketone levels | tumor-induced animal | - | modified | #9 |
ketogenic diet along with its combination such as oxyresveratrol and zinc | decrease | tumor burden | tumor-induced animal | - | supported to diminish | #10 |
BACKGROUND: To date, there is no effective cure for the highly malignant brain tumor glioblastoma (GBM). GBM is the most common, aggressive central nervous system tumor (CNS). It commonly originates in glial cells such as microglia, oligodendroglia, astrocytes, or subpopulations of cancer stem cells (CSCs). Glucose plays an important role in the, which energy metabolism of normal and cancer cells, but cancer cells exhibit an increased demand for glucose is required for their differentiation and proliferation. The main aim of this study is to explore the anti-cancer efficacy of the ketogenic diet against GBM. Also, this research focuses on the identification of the catalytic action of zinc in epigenetic modulators such as oxyresveratrol and ensures the combinatorial effect in the treatment of GBM. METHOD: In this study, we have evaluated various parameters to understand the therapeutic efficacy of the treatment groups through in vivo experiments against aggressive brain tumors. Intracerebroventricular experiments were performed to induce the tumor in the animals and estimate the tumor burden and proliferative index. Followed by the Morris water maze, an open field test, and rota rod was performed to evaluate the memory and motor coordination. To understand the glucose, and ketone level modification before and after treatment, the level of glucose and ketone was analyzed. Moreover, the zinc level is assessed using flame atomic absorption spectroscopy. RESULTS: The results suggested that the ketogenic diet has an anti-cancer efficacy against C6-induced GBM cell lines. Also, it exerts a synergistic effect with the epigenetic modulator, oxyresveratrol, and zinc against GBM cell lines. Moreover, the treatment groups improved memory and motor coordination and modified the glucose and ketone levels to reduce the tumor burden and Ki-67 proliferative index. CONCLUSION: This study revealed the therapeutic effect of the ketogenic diet along with its combination such as oxyresveratrol and zinc against the C6-induced GBM in the Wistar rats. Also, it improved memory and motor coordination and reduced tumor growth. It also modified the glucose and ketone levels in the tumor-induced animal and supported to diminish the tumor burden.