Augmentation of Interstitial Cystitis-Bladder Pain Syndrome Treatment With Meditation and Yoga: A Randomized Controlled Trial.
Study Goal
The researchers aimed to determine whether adding meditation and yoga to standard care improves treatment response in women with interstitial cystitis-bladder pain syndrome.
Results Summary
The mind-body group showed significantly more treatment responders (72.1% vs. 25.6%) and superior improvements in symptom indices, pain scores, and reduced treatment escalation compared to the control group.
Population
Women with interstitial cystitis-bladder pain syndrome.
Effective Dosage
Commercially available meditation application and standardized yoga tutorial video (specific dosage not detailed).
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
standard care plus meditation and yoga | increase | modified GRA (Global Response Assessment) responders | women with interstitial cystitis-bladder pain syndrome | 31/43 (72.1%) vs 10/39 (25.6%), relative risk [RR] 2.8, 95% CI, 1.6-4.6 | had more GRA responders compared with the control group | #1 |
standard care plus meditation and yoga | increase | ICPI (Interstitial Cystitis Problem Index) scores | women with interstitial cystitis-bladder pain syndrome | RR 1.8, 95% CI, 0.5-3.1 | had superior beneficial change | #2 |
standard care plus meditation and yoga | increase | ICSI (Interstitial Cystitis Symptom Index) scores | women with interstitial cystitis-bladder pain syndrome | RR 1.9, 95% CI, 0.2-3.6 | had superior beneficial change | #3 |
standard care plus meditation and yoga | increase | pain scores | women with interstitial cystitis-bladder pain syndrome | RR 1.4, 95% CI, 0.4-2.5 | had superior beneficial change | #4 |
standard care plus meditation and yoga | decrease | treatment escalation | women with interstitial cystitis-bladder pain syndrome | 2/45 (4.4%) vs 14/42 (33.3%), RR 0.13, 95% CI, 0.03-0.55 | required less treatment escalation than the control group | #5 |
OBJECTIVE: To investigate whether yoga and meditation added to usual care improves treatment response in women with interstitial cystitis-bladder pain syndrome. METHODS: This randomized trial compared women with interstitial cystitis-bladder pain syndrome receiving standard care alone (control group) with those receiving standard care plus meditation and yoga (mind-body group). Standard care was defined as behavioral changes or medications recommended by the American Urological Association. Individuals in the control group received standard care, and those in the mind-body group received standard care augmented with a commercially available meditation application and standardized yoga tutorial video. Both groups continued their current interstitial cystitis-bladder pain syndrome standard care treatments. The primary outcome was the modified GRA (Global Response Assessment), comparing responders (moderately, markedly improved) with nonresponders at 12 weeks. On power analysis assuming α=5% and β=80%, a sample size of 82 participants was required to find 30% difference on the GRA between groups. Weekly GRA scores over 12 weeks were also compared. Secondary outcomes included ICPI (Interstitial Cystitis Problem Index)/ICSI (Interstitial Cystitis Symptom Index), pain, pain interference, anxiety/depression, and self-efficacy scores and treatment escalation over 12 weeks. RESULTS: Among 97 randomized participants (49 mind-body group, 48 control group), groups did not differ in characteristics or symptoms at baseline. The mind-body group had more GRA responders compared with the control group at 12 weeks (31/43 [72.1%] vs 10/39 [25.6%], relative risk [RR] 2.8, 95% CI, 1.6-4.6), corroborated by superior weekly GRA results over 12 weeks. The mind-body group had superior beneficial change on the ICPI (RR 1.8, 95% CI, 0.5-3.1), ICSI (RR 1.9, 95% CI, 0.2-3.6), and pain (RR 1.4, 95% CI, 0.4-2.5) scores than the control group at 12 weeks. The mind-body group required less treatment escalation than the control group (2/45 [4.4%] vs 14/42 [33.3%], RR 0.13, 95% CI, 0.03-0.55). CONCLUSION: The addition of meditation and yoga to standard interstitial cystitis-bladder pain syndrome care was associated with improved treatment response and required fewer additional interventions compared with standard care alone. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT04820855.