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Efficacy of caffeine as an ergogenic aid in multiple cycling time trials.

European journal of applied physiology
May 1, 2025
Ítalo Vinícius et al. (7 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to determine whether caffeine supplementation reliably enhances performance in multiple 4km cycling time trials and to assess individual variability in responsiveness.

Results Summary

Caffeine improved performance in the first supplemented time trial (0.5% and 1.8% in two sessions), with one session showing significant improvement over placebo. However, individual responsiveness varied, with 31-38% of cyclists changing their classification of caffeine response between trials.

Population

Thirteen well-trained cyclists.

Effective Dosage

5 mg/kg.

Duration

Single-dose administration with performance tests at 50 and 80 minutes post-supplementation.

Interactions

None mentioned.

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
caffeine supplementation
increase
performance in the first supplemented TT4km in CAF-1
well-trained cyclists
0.5%
enhanced performance
#1
caffeine supplementation
increase
performance in the first supplemented TT4km in CAF-2
well-trained cyclists
1.8%
enhanced performance
#2
caffeine supplementation
increase
performance in the first supplemented TT4km in CAF-2
well-trained cyclists
-
significantly different from placebo
#3
caffeine supplementation
no change
caffeine effects within and across days
well-trained cyclists
-
good reliability
#4
caffeine supplementation
no change
responsiveness to caffeine between the supplemented trials across days
38% of the cyclists
-
changed their classification of responsiveness
#5
caffeine supplementation
no change
responsiveness to caffeine between the supplemented trials across days
31% of the cyclists
-
changed their classification of responsiveness
#6
Abstract

INTRODUCTION: Evidence that caffeine supplementation is effective to improve performance in cycling time trials has been obtained in single rather than multiple time trials. We investigated whether 5 mg.kg METHODS: After selection of eligible cyclists and familiarization with the TT4km, thirteen well-trained cyclists participated in a balanced placebo-controlled designed with two caffeine sessions (CAF-1 and CAF-2) and a placebo session. In each session, cyclists performed a baseline TT4km before caffeine, and two supplemented TT4km (50 min and 80 min after supplementation). Relative and absolute reliability were obtained through intraclass coefficient correlation and standard error of the measurement (SEM), respectively. The cyclists' performance responses to caffeine were classified as beneficial, unchanged, and adverse by calculating the change between caffeine and placebo relative to SEM. RESULTS: Caffeine enhanced performance in the first supplemented TT4km in CAF-1 and CAF-2 (0.5% and 1.8%, respectively), although only CAF-2 was significantly different from placebo (p < 0.001). Analysis with grouped data showed good absolute and relative reliability of caffeine effects within and across days. However, analysis of individual data showed that 38% and 31% of the cyclists changed their classification of responsiveness to caffeine between the supplemented trials across days. CONCLUSIONS: Despite the good reliability of caffeine to enhance performance in a single TT4km performed within and across days, individual analysis challenged the use of caffeine supplementation protocols based on grouped data.

Medical Subject Headings (MeSH)
HumansCaffeineBicyclingMaleAthletic PerformanceAdultPerformance-Enhancing SubstancesPhysical Endurance
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality85/10
Research Impact Scores
APT Score0.05
Weight Score2.70
Normalized Score0.67
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