Combined mindfulness-based stress reduction and physical activity improved psychological factors and sleep quality in patients with MDD: A randomized controlled trial study.
Study Goal
The researchers aimed to evaluate the effectiveness of combining Mindfulness-Based Stress Reduction (MBSR) and physical activity (PA) as an augmentation to sertraline treatment for improving sleep quality and psychological factors in patients with major depressive disorder (MDD).
Results Summary
The study found that MBSR combined with PA (MBSRPA) had more positive impacts on perceived stress, anxiety, depressive symptoms, and sleep quality compared to control and standalone interventions. Sleep disturbance and psychological problems were reduced in all intervention groups over time, with the greatest improvements observed in the MBSRPA group.
Population
Outpatients diagnosed with MDD for at least 2 months (mean age: 35.32 ± 7.8; 65% female) currently on sertraline treatment.
Effective Dosage
Not specified
Duration
8 weeks of intervention, with follow-up at 12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
mindfulness-based stress reduction (MBSR) | increase | sleep quality | - | - | are available to improve | #1 |
physical activity (PA) | increase | sleep quality | - | - | are available to improve | #2 |
combination of MBSR and PA interventions as an augmentation to treatment as usual with sertraline | increase | sleep and psychological factors | patients with MDD | - | aimed to evaluate the effectiveness | #3 |
Physical activity | decrease | sleep disturbance and psychological problems | patients in outpatient care diagnosed with MDD | - | reduced | #4 |
MBSR | decrease | sleep disturbance and psychological problems | patients in outpatient care diagnosed with MDD | - | reduced | #5 |
Combination MBSR and physical activity (MBSRPA) | decrease | sleep disturbance and psychological problems | patients in outpatient care diagnosed with MDD | - | reduced | #6 |
MBSRPA | increase | perceived stress, anxiety, depressive symptoms and sleep quality | patients in outpatient care diagnosed with MDD | - | had a more positive impacts on | #7 |
MBSRPA as an augmentation to standard therapy | decrease | symptoms of depression, anxiety, perceived stress, and sleep problems | patients with MDD | - | confirmed the effectiveness | #8 |
Non-pharmacological interventions are available to improve sleep quality including mindfulness-based stress reduction (MBSR) and physical activity (PA). The present study aimed to evaluate the effectiveness of the combination of MBSR and PA interventions as an augmentation to treatment as usual with sertraline to improve sleep and psychological factors among patients with MDD. Sixty-seven patients in outpatient care diagnosed with MDD for a minimum of 2 months (mean age: 35.32 ± 7.8; 65 % female) and currently on sertraline treatments were randomized into four groups including: 1) Physical activity, 2) MBSR, 3) Combination MBSR and physical activity (MBSRPA), and 4) Control. All participants completed self-reported questionnaires on sleep quality, depression, anxiety, and perceived stress from baseline to 8 weeks later at post-test and four weeks later at follow-up. Over time, sleep disturbance and psychological problems were reduced in all conditions when compared to the control. Moreover, MBSRPA had a more positive impacts on perceived stress, anxiety, depressive symptoms and sleep quality. The results of the present study confirmed the effectiveness of MBSRPA as an augmentation to standard therapy to help reduce symptoms of depression, anxiety, perceived stress, and sleep problems in patients with MDD.