Measuring the effects of ketogenic diet on neuropsychiatric disorder: A scoping review.
Study Goal
The researchers aimed to examine the ketogenic diet's efficiency as a potential therapeutic intervention for various neuropsychiatric disorders.
Results Summary
The review found that the ketogenic diet showed improvements in symptoms across multiple neuropsychiatric disorders, including ADHD, autism, and depressive disorders, but the evidence was heterogeneous, indicating a need for further rigorous research.
Population
Patients with neuropsychiatric disorders (e.g., ADHD, autism, depressive disorders, seizure disorders).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
ketogenic diet | increase | Global Developmental Delay | - | - | improvements in | #1 |
ketogenic diet | increase | Childhood Autism | - | - | improvements in | #2 |
ketogenic diet | increase | Attention Deficit/Hyperactivity Disorder (ADHD) symptoms | - | - | improvements in | #3 |
ketogenic diet | increase | psychotic symptoms | - | - | improvements in | #4 |
ketogenic diet | increase | Bipolar and Related Disorders | - | - | improvements in | #5 |
ketogenic diet | increase | Depressive Disorder symptoms | - | - | improvements in | #6 |
ketogenic diet | increase | anxiety symptoms | - | - | improvements in | #7 |
ketogenic diet | increase | eating disorders | - | - | improvements in | #8 |
ketogenic diet | increase | Substance-Related and Addictive Disorders | - | - | improvements in | #9 |
ketogenic diet | increase | Major and Mild Neurocognitive Disorders | - | - | improvements in | #10 |
ketogenic diet | increase | Seizure Disorders | - | - | improvements in | #11 |
OBJECTIVE: This scoping review aims to examine the available literature on the ketogenic diet's (KD) efficiency as a potential therapeutic intervention for various neuropsychiatric disorders. INTRODUCTION: The KD is a high-fat, low-carbohydrate diet that has been studied for its potential benefits in managing neuropsychiatric disorders. However, the extent of its effectiveness across a spectrum of these conditions remains unclear. INCLUSION CRITERIA: The study designs considered eligible encompassed randomized and non-randomized controlled trials, retrospective and prospective observational studies, and comparative effectiveness assessments. The criteria for including each study were specifically related to neuropsychiatric disorders, referring to the DSM-5 coding guidelines. METHODS: A systemic search was performed by an experienced reference librarian across multiple databases to pinpoint studies relevant to the influence of the ketogenic diet on neuropsychiatric disorders. All relevant articles were included that ranged over the last thirteen years. All relevant records identified were compiled into the Covidence systematic review software. RESULTS: A total of 30 studies were reviewed, which reported effects of the KD on neuropsychiatric disorders, including improvements in Global Developmental Delay, Childhood Autism, Attention Deficit/Hyperactivity Disorder (ADHD) symptoms, psychotic symptoms, Bipolar and Related Disorders, Depressive Disorder symptoms, anxiety symptoms, eating disorders, Substance-Related and Addictive Disorders, Major and Mild Neurocognitive Disorders, and Seizure Disorders. CONCLUSION: The KD may serve as a promising therapeutic intervention for various neuropsychiatric disorders. However, the evidence is heterogeneous, and further rigorous research is needed to establish the KD as a standard treatment for these disorders and to understand the underlying mechanisms of its effects. IMPLICATIONS FOR PRACTICE: This review underscores the need for healthcare professionals to consider the potential benefits and limitations of the KD when managing patients with neuropsychiatric disorders. It also highlights the importance of individualized treatment plans based on the specific needs and responses of each patient.