Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people.
Study Goal
The researchers aimed to determine whether high-pressure-processed (HPP) rice intake during interval walking training (IWT) improved glycemic control and enhanced methylation of the NFKB2 gene in hyperglycemic older adults.
Results Summary
HPP rice intake during IWT led to improved glycemic control, including reduced variability in fasting blood glucose and decreased post-breakfast glucose levels, with changes correlated to NFKB2 gene methylation. The effects were statistically significant but modest in magnitude.
Population
Hyperglycemic older adults (~70 years) who had already performed IWT for ≥6 months.
Effective Dosage
75 g dry weight of HPP rice at breakfast and dinner.
Duration
4 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
HPP rice intake during interval walking training (IWT) | decrease | mean fasting blood glucose concentration ([Glc]) values for 180 min before breakfast over 4 days (days 2-5) | hyperglycemic older subjects | - | marginally decreased | #1 |
HPP rice intake during interval walking training (IWT) | decrease | standard deviation of blood glucose concentration ([Glc]) during the 180 min before breakfast over 4 days (days 2-5) | hyperglycemic older subjects | - | decreased more | #2 |
HPP rice intake during interval walking training (IWT) | decrease | total area under the curve (tAUC) for blood glucose concentration ([Glc]) for 180 min after breakfast on day 5 | hyperglycemic older subjects | - | decreased more | #3 |
HPP rice intake during interval walking training (IWT) | decrease | change in total area under the curve (tAUC) for blood glucose concentration ([Glc]) on day 5 after the intervention | hyperglycemic older subjects | - | was negatively correlated with | #4 |
HPP rice intake during interval walking training (IWT) | increase | glycemic control | hyperglycemic older people | - | improved | #5 |
HPP rice intake during interval walking training (IWT) | no change | NFKB2 gene methylation | hyperglycemic older people | - | suppressed reduction in | #6 |
PURPOSE: High-pressure-processed (HPP) rice is white rice that maintains some key functional food ingredients of brown rice, such as polyphenols. We examined whether HPP rice intake during interval walking training (IWT) improved glycemic control with enhanced methylation of the NFKB2 gene in hyperglycemic older subjects. METHODS: We recruited 51 people aged ~ 70 yr who had already performed IWT for ≥ 6 months, but had hyperglycemia (blood glucose concentration ([Glc]) > 110 mg/dl or HbA1c > 6.0% while fasting). Participants were randomly divided into control (CNT) or HPP rice (HPR) groups and instructed to perform IWT for an additional 4 months while ingesting 75 g dry weight of either white rice or HPP rice, respectively, at every breakfast and dinner. Before and after intervention, [Glc] was measured by continuous glucose monitoring for 5 days, with standardized breakfast on day 5. Methylation of NFKB2 was measured by pyrosequencing. RESULTS: After intervention, mean fasting [Glc] values for 180 min before breakfast over 4 days (days 2-5) marginally decreased in HPR but were not different from CNT (P = 0.17). However, the standard deviation during the period decreased more in HPR than in CNT (P = 0.013). Moreover, total area under the curve (tAUC) for 180 min after breakfast on day 5 decreased more in HPR than in CNT (P = 0.035). The change in tAUC on day 5 after the intervention was negatively correlated with that in NFKB2 gene methylation (P = 0.002). CONCLUSION: HPP rice intake during IWT improved glycemic control with suppressed reduction in NFKB2 gene methylation in hyperglycemic older people. TRIAL REGISTRATION NUMBER AND DATE OF REGISTRATION: UMIN000024390; October 13, 2016.