Proximal Muscle Resistance Training to Improve Walking in People With Multiple Sclerosis: A Pilot Study.
Study Goal
The researchers aimed to assess the feasibility and effects of a proximal muscle resistance training program on walking and muscle performance in people with multiple sclerosis.
Results Summary
The study found significant improvements in walking distance (6-Minute Walk Test), walking speed (Timed 25-Foot Walk Test), and muscle performance, with high participant satisfaction and no serious adverse events. No changes were observed in daily step count or trunk/pelvis kinematics.
Population
People with multiple sclerosis (Expanded Disability Status Scale Score <6.0, median score 3.5).
Effective Dosage
Resistance training targeting hip abduction and trunk muscles (specific dosage not detailed).
Duration
10 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
proximal muscle resistance training program | increase | 6-Minute Walk Test distance | people with multiple sclerosis | 29.6 m | increased | #1 |
proximal muscle resistance training program | decrease | Timed 25-Foot Walk Test | people with multiple sclerosis | 0.57 seconds | decreased | #2 |
proximal muscle resistance training program | increase | muscle performance outcomes | people with multiple sclerosis | - | improved | #3 |
proximal muscle resistance training program | increase | patient-reported outcomes | people with multiple sclerosis | - | improved | #4 |
proximal muscle resistance training program | no change | average daily step count | people with multiple sclerosis | - | no changes | #5 |
proximal muscle resistance training program | no change | trunk and pelvis kinematics | people with multiple sclerosis | - | no changes | #6 |
BACKGROUND AND PURPOSE: This pilot study examined the feasibility of a proximal muscle resistance training program to improve walking in people with multiple sclerosis using a combination of in-person, virtual, and independent exercise sessions. METHODS: People with multiple sclerosis (Expanded Disability Status Scale Score is <6.0) were recruited to a study of resistance training exercises targeting hip abduction and trunk muscles for 10 weeks. Feasibility criteria were: enrolling 40 participants, retaining ≥80%, ≥80% visit adherence, no serious intervention-related adverse events, and ≥80% satisfaction. The 6-Minute Walk Test, Timed 25-Foot Walk Test, muscle performance (hip abduction and lateral trunk flexion strength, and trunk flexion endurance), patient-reported outcomes, daily step count, and pelvis and trunk kinematics were measured before and after intervention. Patient-reported outcomes and step count were measured again 12 weeks after intervention. RESULTS: Twenty-eight people (median Expanded Disability Status Scale is 3.5) enrolled and 92.8% were retained. Visit adherence was 86.5% (96% for virtual visits, 74% for in-person visits), and 48% of participants preferred virtual visits, while 20% preferred in-person visits. There were no serious intervention-related adverse events, and there was 100% satisfaction. Following intervention, 6-Minute Walk Test distance increased 29.6 m (95% confidence interval [CI], 12.2-47.0), Timed 25-Foot Walk Test decreased by 0.57 seconds (95% CI, -0.85 to -0.29), and all muscle performance outcomes improved. Patient-reported outcomes also improved immediately following intervention. There were no changes in average daily step count or trunk and pelvis kinematics. DISCUSSION AND CONCLUSIONS: This proximal muscle resistance training program was feasible, with benefits in walking and muscle strength, warranting a future efficacy study. UNLABELLED: Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A499 ).