The Effect of Vitamin D Supplementation on Quality of Life in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy: A Single-Blind, Randomized Controlled Trial.
Study Goal
The researchers aimed to determine whether vitamin D supplementation could improve the quality of life in stage II-III colorectal cancer patients undergoing adjuvant chemotherapy.
Results Summary
Vitamin D supplementation (10,000 IU/day) significantly increased serum vitamin D levels and improved quality of life scores at the third and sixth months post-chemotherapy compared to placebo.
Population
Stage II-III colorectal cancer patients undergoing adjuvant chemotherapy at Hasan Sadikin Hospital.
Effective Dosage
10,000 IU/day
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | increase | serum vitamin D levels | stage II-III colorectal cancer patients undergoing adjuvant chemotherapy | from a median of 21.34 (5.26-29.95) to 27.92 (13.58-40.49) | significantly increased | #1 |
placebo | decrease | serum vitamin D levels | stage II-III colorectal cancer patients undergoing adjuvant chemotherapy | from a median of 22.78 (8.3-29.93) to 21.37 (7.45-31.26) | decreased | #2 |
vitamin D consumption (10,000 IU/day) | increase | quality of life | colorectal cancer patients undergoing adjuvant chemotherapy | median of 75.0 vs 45.83 on the third month, median of 83.33 vs 33.33 on the sixth month | improved significantly | #3 |
INTRODUCTION: Colorectal cancer is the third most common cancer with the second highest mortality worldwide in 2020. Adjuvant chemotherapy is given for stage II-III colorectal cancer. However, there are side effects that decrease the patient's quality of life. Several studies have found that vitamin D could reduce the side effects of chemotherapy, but studies at Hasan Sadikin Hospital have not been done. METHODS: A study regarding the effect of vitamin D supplementation on the quality of life of stage II-III colorectal cancer patients undergoing adjuvant chemotherapy from May 2022 to April 2023 at Hasan Sadikin Hospital was conducted. A single-blinded, randomized controlled trial (RCT) with consecutive sampling was done at the digestive surgery outpatients. Data was taken from the medical record, history taking, and personal interviews. Quality of life was measured at the first, third, and sixth months after chemotherapy using the validated Indonesian version of the EORTC QLQ-C30 questionnaire. RESULTS: A total of 34 patients received vitamin D and 34 others received placebo. Serum vitamin D levels significantly increased (p < 0.001) in the intervention arm, from a median of 21.34 (5.26-29.95) to 27.92 (13.58-40.49). Meanwhile, it decreased in the placebo arm, from a median of 22.78 (8.3-29.93) to 21.37 (7.45-31.26). The patient's quality of life improved significantly after receiving vitamin D, compared with the placebo group on the third (median of 75.0 vs 45.83) and sixth (median of 83.33 vs 33.33) months after chemotherapy. CONCLUSION: Vitamin D consumption (10,000 IU/day) could improve the quality of life of colorectal cancer patients undergoing adjuvant chemotherapy.