Effect of vitamin D adjuvant therapy on the proportion of regulatory T cells in peripheral blood and pregnancy outcome of patients with recurrent miscarriage.
Study Goal
The researchers aimed to determine whether adjuvant Vitamin D therapy could improve regulatory T cell proportions, metabolic factors, immune inflammation, and pregnancy outcomes in recurrent miscarriage patients.
Results Summary
Vitamin D adjuvant therapy significantly increased regulatory T cell proportions, improved metabolic markers (lower triglycerides, leptin, fasting glucose, and insulin; higher adiponectin), reduced inflammatory markers (interleukin-17, gamma interferon, tumor necrosis factor-α, C-reactive protein), and led to higher pregnancy success rates and lower preterm birth rates compared to the control group.
Population
104 individuals with recurrent miscarriage (52 in Vitamin D group, 52 in control group).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D adjuvant therapy | increase | proportion of regulatory T cells | RM patients | - | considerably higher | #1 |
Vitamin D adjuvant therapy | decrease | triglyceride levels | RM patients | - | lower | #2 |
Vitamin D adjuvant therapy | decrease | leptin | RM patients | - | lower | #3 |
Vitamin D adjuvant therapy | decrease | fasting blood glucose | RM patients | - | lower | #4 |
Vitamin D adjuvant therapy | decrease | fasting insulin | RM patients | - | lower | #5 |
Vitamin D adjuvant therapy | increase | adiponectin levels | RM patients | - | higher | #6 |
Vitamin D adjuvant therapy | increase | progesterone | RM patients | - | higher | #7 |
Vitamin D adjuvant therapy | increase | luteinizing hormone | RM patients | - | higher | #8 |
Vitamin D adjuvant therapy | increase | 25-hydroxy VD | RM patients | - | higher | #9 |
Vitamin D adjuvant therapy | decrease | interleukin-17 | RM patients | - | lower | #10 |
Vitamin D adjuvant therapy | decrease | gamma interferon | RM patients | - | lower | #11 |
Vitamin D adjuvant therapy | decrease | tumor necrosis factor-α | RM patients | - | lower | #12 |
Vitamin D adjuvant therapy | decrease | C-reactive protein | RM patients | - | lower | #13 |
Vitamin D adjuvant therapy | increase | pregnancy success rate | RM patients | - | higher | #14 |
Vitamin D adjuvant therapy | decrease | preterm birth rate | RM patients | - | lower | #15 |
BACKGROUND: Recurrent miscarriage (RM) is influenced by immune factors, particularly regulatory T cells, which can impact immune function and miscarriage risk. Vitamin D (VD) is known to regulate the immune system, potentially improving pregnancy outcomes in RM patients. This study aims to assess the effect of VD adjuvant therapy on regulatory T cells and pregnancy outcomes in RM patients. METHODS: Clinical data from 104 individuals with RM admitted to our hospital between March 2022 and February 2023 were allocated at random to either the VD group (VDG) or the control group (CG), with 52 patients in each group. Both groups received standard treatment; the CG was treated with aspirin, while the VDG received additional VD therapy. Outcomes measured included regulatory T cell proportion, metabolic factors, immune inflammatory markers, and pregnancy outcomes. RESULTS: After treatment, the proportion of regulatory T cells in VDG was considerably higher (p < 0.05). Additionally, triglyceride levels, leptin, fasting blood glucose, and fasting insulin were lower in the VDG, whereas adiponectin levels were higher (p < 0.05). Levels of progesterone, luteinizing hormone, and 25-hydroxy VD were also higher in the VDG (p < 0.05). Furthermore, interleukin-17, gamma interferon, tumor necrosis factor-α, and C-reactive protein were lower in the VDG (p < 0.05). The pregnancy success rate in the VDG was higher, and the preterm birth rate was lower (p < 0.05). CONCLUSION: Adjuvant treatment with VD can increase the proportion of regulatory T cells in peripheral blood of individuals with recurrent abortion, regulate metabolic disorder, alleviate immune inflammation, and improve pregnancy outcome.