Comparative Efficacy of Magnesium and Potassium Towards Cholesterol and Quality of Life in Patients With Type 2 Diabetes Mellitus: A Randomised Single-Blinded Controlled Clinical Trial.
Study Goal
The researchers aimed to compare the effects of magnesium, potassium, and their combination on cholesterol levels and quality of life in patients with type 2 diabetes mellitus.
Results Summary
Magnesium supplementation led to a significant improvement in social quality of life and contributed to a decrease in cholesterol levels, though the largest reduction was observed with potassium. The combined effect of magnesium and potassium was beneficial for hyperlipidaemia in T2DM patients.
Population
290 patients with type 2 diabetes mellitus.
Effective Dosage
Not specified
Duration
60 days
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
potassium supplements | decrease | cholesterol levels | patients with T2DM | 224.9 ± 61.92 to 163.4 ± 48.38 | decrease in mean cholesterol levels | #1 |
magnesium supplements | increase | social quality of life (QoL) | patients with T2DM | p value change from 0.06 to 0.000 | significant increase in the social QoL | #2 |
potassium supplements | increase | social quality of life (QoL) | patients with T2DM | p value change from 0.06 to 0.000 | significant increase in the social QoL | #3 |
magnesium- and potassium-based formulations | decrease | cholesterol levels | patients with T2DM | - | overall decrease in cholesterol levels | #4 |
magnesium- and potassium-based formulations | increase | social quality of life (QoL) | patients with T2DM | - | improvement in the social QoL | #5 |
UNLABELLED: Previous studies exploring the relationship between dietary potassium and magnesium intake and the risk of type 2 diabetes mellitus (T2DM) have yielded inconsistent results. OBJECTIVE: The present study was designed to compare the effect of magnesium, potassium and both (potassium and magnesium combined) on cholesterol levels and quality of life (QoL) among patients with T2DM. METHODS: A randomised controlled trial (single blinded) was conducted at The University of Lahore and Lahore Medical Research Center (LMRC). The sample size was 290 patients with T2DM, who were divided into four groups: Group I (T1) that received control/placebo; Group II (T2) and Group III (T3) received magnesium and potassium supplements, respectively; and Group IV (T4) received both magnesium and potassium supplements. Blood samples were taken from all patients before and after 60 days of supplementation to determine the levels of K RESULTS: There was a decrease in mean cholesterol levels in all groups after the treatment, with the largest reduction (224.9 ± 61.92 to 163.4 ± 48.38) seen in the T3 group, that received potassium supplements. A significant increase in the social QoL, indicated by a p value change from 0.06 before medical intervention to 0.000 after medical intervention, was observed. p value was significant (<0.05) between pre- and post-QoL within the T2 (Mg) and T3 (K) treatment groups. CONCLUSIONS: The overall decrease in cholesterol levels and improvement in the social QoL after treatment imply that magnesium- and potassium-based formulations prove beneficial in combating hyperlipidaemia in patients with T2DM. TRIAL REGISTRATION: NCT04642313.