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Nutritional strategies for improving sarcopenia outcomes in older adults: A narrative review.

Pharmacology research & perspectives
October 1, 2024
Beatriz R Goes-Santos et al. (4 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review the evidence on the impact of branched-chain amino acids (BCAAs) on sarcopenia outcomes in older adults.

Results Summary

The abstract states that the impact of BCAAs on sarcopenia and related outcomes remains unclear, suggesting insufficient or mixed evidence.

Population

Older adults with or at risk of sarcopenia.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (2)
InterventionDirectionEndpointPopulationDosageImpactClaim #
animal (i.e., whey protein) and plant-based protein, leucine, and creatine
increase
outcomes related to sarcopenia
-
-
have been shown to play a significant role in improving
#1
other supplements (e.g., branched-chain amino acids, isolated amino acids, and omega-3)
no change
sarcopenia and related outcomes
-
-
impact on sarcopenia and related outcomes remain unclear
#2
Abstract

Sarcopenia is characterized by a decline in muscle strength, generalized loss of skeletal muscle mass, and impaired physical performance, which are common outcomes used to screen, diagnose, and determine severity of sarcopenia in older adults. These outcomes are associated with poor quality of life, increased risk of falls, hospitalization, and mortality in this population. The development of sarcopenia is underpinned by aging, but other factors can lead to sarcopenia, such as chronic diseases, physical inactivity, inadequate dietary energy intake, and reduced protein intake (nutrition-related sarcopenia), leading to an imbalance between muscle protein synthesis and muscle protein breakdown. Protein digestion and absorption are also modified with age, as well as the reduced capacity of metabolizing protein, hindering older adults from achieving ideal protein consumption (i.e., 1-1.5 g/kg/day). Nutritional supplement strategies, like animal (i.e., whey protein) and plant-based protein, leucine, and creatine have been shown to play a significant role in improving outcomes related to sarcopenia. However, the impact of other supplements (e.g., branched-chain amino acids, isolated amino acids, and omega-3) on sarcopenia and related outcomes remain unclear. This narrative review will discuss the evidence of the impact of these nutritional strategies on sarcopenia outcomes in older adults.

Medical Subject Headings (MeSH)
HumansSarcopeniaAgedDietary SupplementsMuscle, SkeletalAgingDietary ProteinsMuscle StrengthQuality of LifeAged, 80 and overMuscle Proteins
Study Links
Quality Scores
SafetyNot Assessed
Efficacy50/10
Quality70/10
Citation Metrics
Total Citations3
Citations/Year3.0
Research Impact Scores
APT Score0.50
Weight Score2.56
Normalized Score0.54
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