Effect of low vs high dietary-advanced glycation end products on insulin-sensitivity and inflammatory- markers among overweight/obese Asian-Indian adults-A randomised controlled trial.
Study Goal
The researchers aimed to compare the effects of low vs high dietary Advanced Glycation End Products (dAGE) diets on β-cell function and cardiometabolic risk factors in overweight and obese Asian Indian adults.
Results Summary
The low-dAGE diet significantly improved oral disposition index (a marker of β-cell function), reduced post-glucose challenge values, and lowered serum AGEs and inflammatory levels compared to the high-dAGE diet. These findings suggest low-dAGE diets may reduce diabetes risk.
Population
Overweight and obese Asian Indian adults aged 25-45 years with BMI ≥23 kg/m².
Effective Dosage
Not specified
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-dAGE diet | increase | oral disposition index | overweight and obese Asian Indian adults | +0.3 (0.1) Least Square Mean (SE) | significantly improved | #1 |
low-dAGE diet | decrease | 30-minutes plasma post-glucose-challenge-value | overweight and obese Asian Indian adults | -8.1[3.8] (mg/dl) vs 3.8 [3.8] (mg/dl) | significant reduction | #2 |
low-dAGE diet | decrease | serum-AGEs | overweight and obese Asian Indian adults | -3.2 [0.2] (μg/ml) vs -0.8 [0.2] (μg/ml) | significant reduction | #3 |
low-dAGE diet | increase | insulin-sensitivity | overweight and obese Asian Indian adults | - | exhibited improvement | #4 |
low-dAGE diet | decrease | inflammatory levels | overweight and obese Asian Indian adults | - | reduction | #5 |
low dAGE diets | decrease | diabetes risk | - | - | could be a potential strategy to reduce | #6 |
The present study investigated the effect of low vs high-dietary-Advanced Glycation End products-based diets on oral disposition index-(DIo)-a marker of islet β-cell function and cardiometabolic risks factors in 38-overweight and obese Asian Indian-adults (aged 25-45 years with body-mass-index (BMI) ≥23kg/m2) through 12-week isocaloric crossover feeding trial. Biochemical-measures included-glucose tolerance test (GTT), Insulin assay (0,30 and 120 min), lipid-profile, serum-adiponectin, serum-AGE and serum-Thiobarbituric acid reactive substances-(TBARS) assessed both at baseline and end of each intervention. Generalised linear models showed that low-dAGE diet significantly improved in oral disposition index [Least Square Mean (SE), +0.3 (0.1); p = 0.03] compared to high-dAGE diet. The low-dAGE diet also showed a significant reduction in 30-minutes plasmapost-glucose-challenge-value:(-8.1[3.8] (mg/dl) vs 3.8 [3.8] (mg/dl); p = 0.01), serum-AGEs-(-3.2 [0.2] (μg/ml) vs -0.8 [0.2] (μg/ml); p = <0.0001) compared to high-dAGE diet. In summary, low-dAGE diets exhibited improvement in the insulin-sensitivity and reduction in the inflammatory levels compared to high-dAGE diets. Hence, study first time in India revealed that low dAGE diets could be a potential strategy to reduce diabetes risk.