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Normocytic Anemia in Pregnant Women: A Scoping Review.

The Medical journal of Malaysia
September 1, 2024
S A Sharief et al. (5 authors)
Journal ArticleScoping ReviewHuman Study
Study Details

Study Goal

The researchers aimed to identify the underlying causes of normocytic anemia in pregnant women, particularly in developing countries, beyond just iron deficiency.

Results Summary

The study found that malaria and HIV were the highest causes of normocytic anemia in pregnant women, followed by worm/intestinal parasite infections, chronic diseases, and bleeding. Anemia of chronic disease and infection often coexisted with iron deficiency anemia, complicating diagnosis.

Population

Pregnant women in developing countries, specifically Indonesia.

Effective Dosage

90 iron tablets during pregnancy (exact dosage per tablet not specified).

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (10)
InterventionDirectionEndpointPopulationDosageImpactClaim #
iron supplementation program
decrease
anemia
pregnant women
-
is the main program for tackling
#1
90 iron tablets
neutral
-
expectant mothers
-
is recommended that expectant mothers ingest
#2
-
neutral
anemia
37% of pregnant women in the country
-
experience
#3
iron deficiency
neutral
anemia
-
-
emerges as the primary etiology for diagnosing
#4
chronic illnesses and infections
increase
anemia
-
-
significantly contribute to the prevalence of
#5
malaria and HIV
increase
normocytic anemia
pregnant women
-
were the highest causes of
#6
worm/intestinal parasite infections, chronic diseases, and bleeding
increase
normocytic anemia
pregnant women
-
followed as causes of
#7
anemia of chronic disease and infection
neutral
iron deficiency anemia
pregnant women
-
coexists with
#8
anemia of chronic disease and infection
decrease
serum iron levels
-
-
show
#9
iron deficiency anemia
decrease
serum iron levels
-
-
show
#10
Abstract

INTRODUCTION: The iron supplementation program for pregnant women is the main program for tackling anemia in various countries, especially in developing countries in which daily diets may lack sufficient iron intake. In Indonesia, it is recommended that expectant mothers ingest 90 iron tablets during their pregnancy; however, the World Health Organization reports that 37% of pregnant women in the country continue to experience anemia. Iron deficiency anemia consistently emerges as the primary etiology for diagnosing anemia; however, it is important to recognize that anemia can stem from various factors beyond just lack of iron. In addition to iron deficiency, chronic illnesses and infections significantly contribute to the prevalence of anemia worldwide. Consequently, this literature review endeavors to uncover the underlying factors responsible for normocytic anemia among pregnant women, focusing on developing countries. MATERIALS AND METHODS: Eight search engines, specifically Proquest, EbscoHost, Scopus, Cochrane Library, Science Direct, Wiley Online Library, PubMed, Google Scholar, and Garuda, were utilized to identify primary articles. Three independent reviewers assessed abstracts and full articles based on specific inclusion and exclusion criteria. The data collected encompassed information regarding the population under study, research methods employed, and primary findings pertinent to the review's objectives. Fifteen studies, published between 2014 and 2023, that met the eligibility criteria outlined in the PRISMA-ScR. RESULTS: Among the 15 studies on normocytic anemia in pregnant women, malaria and HIV were the highest causes of normocytic anemia, followed by worm/intestinal parasite infections, chronic diseases, and bleeding.. In pregnant women, anemia of chronic disease and infection often coexists with iron deficiency anemia, both show decrease serum iron levels. Hence, other investigations need to be carried out to diagnose with certainty the cause of anemia in pregnant women. CONCLUSION: Anemia is not a standalone disease but rather a symptom of various underlying diseases. Therefore, diagnosing anemia requires identifying the basic disease that causes anemia, rather than simply labeling it as anemia.

Medical Subject Headings (MeSH)
HumansFemalePregnancyPregnancy Complications, HematologicAnemia, Iron-DeficiencyAnemiaIron
Study Links
PubMed ID39352168
Quality Scores
SafetyNot Assessed
Efficacy60/10
Quality75/10
Citation Metrics
Total Citations1
Citations/Year1.0
Research Impact Scores
APT Score0.50
Weight Score2.50
Normalized Score0.59
Related Supplements
Normocytic Anemia in Pregnant Women: A Scoping Review. | Panacea Index