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Influence of vitamin D-calcium on metabolic profile for gestational diabetes: a meta-analysis of randomized controlled trials.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
December 1, 2024
Jin Wang et al. (3 authors)
Journal ArticleMeta-AnalysisHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the efficacy of vitamin D-calcium supplementation in improving metabolic profiles for the treatment of gestational diabetes.

Results Summary

Vitamin D-calcium supplementation significantly reduced fasting plasma glucose and improved metabolic profiles in pregnant women with gestational diabetes compared to the control group. The meta-analysis included five RCTs with consistent positive outcomes.

Population

Pregnant women with gestational diabetes (306 participants across five studies).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
vitamin D-calcium supplementation
decrease
fasting plasma glucose
pregnant women with gestational diabetes
SMD=-0.67; 95% CI=-0.93 to -0.41
was associated with remarkably decreased
#1
vitamin D-calcium supplementation
decrease
fasting insulin
pregnant women with gestational diabetes
SMD=-0.73; 95% CI=-1.07 to -0.39
was associated with remarkably decreased
#2
vitamin D-calcium supplementation
decrease
HOMA-IR
pregnant women with gestational diabetes
SMD=-0.73; 95% CI=-1.07 to -0.39
was associated with remarkably decreased
#3
vitamin D-calcium supplementation
increase
metabolic profile
pregnant women with gestational diabetes
-
is effective to improve
#4
Abstract

INTRODUCTION: The use of vitamin D-calcium supplementation for treating gestational diabetes remains unclear. This meta-analysis aims to evaluate the efficacy of vitamin D-calcium supplementation in the treatment of gestational diabetes. METHODS: Several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systemically searched from inception to August 2023, and we included the randomized controlled trials (RCTs) assessing the effect of vitamin D-calcium supplementation on the metabolic profile of gestational diabetes. RESULTS: We included five eligible RCTs and 306 pregnant women in this meta-analysis. Compared with control group in pregnant women with gestational diabetes, vitamin D-calcium supplementation was associated with remarkably decreased fasting plasma glucose (SMD=-0.67; 95% CI=-0.93 to -0.41; CONCLUSIONS: Vitamin D-calcium supplementation is effective to improve metabolic profile for the treatment of gestational diabetes.

Medical Subject Headings (MeSH)
FemaleHumansPregnancyBlood GlucoseCalciumDiabetes, GestationalDietary SupplementsInsulinMetabolomeRandomized Controlled Trials as TopicVitamin D
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Research Impact Scores
APT Score0.05
Weight Score2.34
Normalized Score0.69
Related Supplements
Influence of vitamin D-calcium on metabolic profile for gest... | Panacea Index