Testosterone and resistance training improved physical performance and reduced fatigue in frail older men: 1 year follow-up of a randomized clinical trial.
Study Goal
The researchers aimed to determine whether combining testosterone therapy, progressive resistance training, and oral supplements (including vitamin D) improved physical performance in older hypogonadal men with mobility issues.
Results Summary
The study found that the combination of testosterone supplementation and progressive resistance training improved physical performance (measured by the 30-s chair stand test), but the abstract does not isolate the specific effects of vitamin D supplementation.
Population
Men aged ≥70 years with low testosterone levels and mobility problems.
Effective Dosage
Not specified
Duration
52 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D, calcium, and protein | increase | health conditions | hypogonadal men ≥70 years of age | - | To improve health conditions | #1 |
testosterone therapy (TU) or progressive resistance training (Training), both (Combo), or no intervention (Controls) | increase | 30-s chair stand test performance | older men ≥70 years old with low testosterone levels and mobility problems | - | improved | #2 |
testosterone supplementation combined with progressive resistance training | increase | physical performance | males aged ≥70 suffering from mobility issues and testosterone insufficiency | - | may enhance | #3 |
testosterone supplementation combined with progressive resistance training | decrease | fatigue | males aged ≥70 suffering from mobility issues and testosterone insufficiency | - | alleviate | #4 |
testosterone supplementation combined with progressive resistance training | no change | detrimental impacts | males aged ≥70 suffering from mobility issues and testosterone insufficiency | - | had no notable detrimental impacts | #5 |
OBJECTIVE: To improve health conditions among hypogonadal men ≥70 years of age using testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D, calcium, and protein. METHODS: This study is a 1-year follow-up of a double-blind RCT lasting 20 weeks, including 148 older men ≥70 years old with low testosterone levels and mobility problems. During 52 weeks, 4 groups received either testosterone therapy (TU) or progressive resistance training (Training), both (Combo), or no intervention (Controls). Physiotherapists supported the training groups until week 20, while these participants continued trained on their own during weeks 21 to 52. The main outcome measure was the 30-s chair stand test. RESULTS: The following numbers of participants completed the trial: 20 (Combo), 20 (Controls), 24 (TU), and 14 (Training). When examining 30-s chair stand test performance within each group at baseline, and at weeks 4, 20 and 52, only the Combo group improved ( CONCLUSIONS: Fifty-two weeks of testosterone supplementation combined with progressive resistance training may enhance physical performance, alleviate fatigue, and had no notable detrimental impacts among males aged ≥70 suffering from mobility issues and testosterone insufficiency.