Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial.
Study Goal
The researchers aimed to evaluate the effects of the MIND diet (a combination of Mediterranean and DASH diets) and propolis supplementation on metabolic syndrome indices, cognitive function, and other health markers in adults with MetS.
Results Summary
The study found that propolis supplementation led to significant reductions in fasting plasma glucose levels and improved lipid profiles, suggesting potential benefits when combined with the MIND diet for metabolic and cognitive health.
Population
Adults with metabolic syndrome visiting Hazrat Ali Health Center in Isfahan.
Effective Dosage
Not specified
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
propolis supplementation | decrease | fasting plasma glucose levels | - | - | a significant reduction | #1 |
propolis supplementation | decrease | lipid profiles | - | - | a significant reduction | #2 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | blood sugar | - | - | will improve | #3 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | blood lipid | - | - | will improve | #4 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | anthropometric indicators | - | - | will improve | #5 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | blood pressure | - | - | will improve | #6 |
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet | increase | cognitive function | - | - | will improve | #7 |
propolis supplement | increase | blood sugar | - | - | will improve | #8 |
propolis supplement | increase | blood lipid | - | - | will improve | #9 |
propolis supplement | increase | anthropometric indicators | - | - | will improve | #10 |
propolis supplement | increase | blood pressure | - | - | will improve | #11 |
propolis supplement | increase | cognitive function | - | - | will improve | #12 |
Metabolic syndrome (MetS) is the main general and clinical health challenge worldwide. Based on the National Cholesterol Education Program, if the person has three or more indices containing: elevated fasting blood sugar, high levels of triglycerides, hypertension, low levels of high-density lipoprotein cholesterol, and central obesity, he suffers MetS. The Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay diet is a novel diet that with the specific aim of safeguarding cognitive function. Propolis is a resinous substance produced by bees from the combination of buds and secretions of plants with saliva and bee enzymes. After propolis supplementation, a significant reduction in fasting plasma glucose levels and lipid profiles has been observed. Considering the importance of chronic diseases like MetS on health, the role of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and propolis supplement that will improve blood sugar, blood lipid, anthropometric indicators, blood pressure, and cognitive function, and limited contradictory studies, we decided to conduct this study. This study, which is a randomized controlled clinical trial study, will be conducted on adults with MetS who will visit Hazrat Ali Health Center in Isfahan. Participants must provide informed consent before engaging in the study. Demographic data such as age, gender, and medical history will be recorded. Then, anthropometric indices, MetS indices, and cognitive function will be measured in all subjects. The study participants will be divided into three groups and will be controlled for 12 weeks. We will have a MIND diet + placebo group, a MIND diet + propolis supplement group, and a control group that will receive a microcrystalline cellulose placebo and usual dietary advice. At the end of the intervention, all indices will be assessed again. The data obtained in the study will be analyzed at descriptive and analytical levels by the statistical software SPSS26. The present study's protocol was approved by the Iranian Registry of Clinical Trials (www.irct.ir) on 3/28/2023 and a registration reference is IRCT20230105057054N1.