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Development of an anti-inflammatory diet for first-episode psychosis (FEP): a feasibility study protocol.

Frontiers in nutrition
May 5, 2024
Leda Kennedy et al. (6 authors)
Journal ArticleHuman Study
Study Details

Study Goal

The researchers aimed to design and assess the feasibility of an anti-inflammatory diet intervention for individuals with first-episode psychosis (FEP) to address inflammation and metabolic health.

Results Summary

The study developed a flexible anti-inflammatory diet based on existing research and refined it through focus groups. The feasibility phase is currently testing acceptability and measuring changes in inflammatory biomarkers, metabolic health, and symptoms, but results are preliminary.

Population

First-episode psychosis (FEP) participants aged 15-30.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (5)
InterventionDirectionEndpointPopulationDosageImpactClaim #
anti-inflammatory diet intervention (DI)
decrease
high rates of metabolic disease
first-episode psychosis (FEP) population
-
address
#1
anti-inflammatory diet intervention (DI)
neutral
acceptability of the DI
small cohort of FEP participants (N = 12)
-
administered
#2
anti-inflammatory diet intervention (DI)
neutral
naturalistic changes in inflammatory biomarkers
small cohort of FEP participants (N = 12)
-
measured
#3
anti-inflammatory diet intervention (DI)
neutral
naturalistic changes in metabolic health
small cohort of FEP participants (N = 12)
-
measured
#4
anti-inflammatory diet intervention (DI)
neutral
naturalistic changes in symptoms
small cohort of FEP participants (N = 12)
-
measured
#5
Abstract

BACKGROUND: Evidence suggests inflammation plays a role in the pathophysiology of psychosis even in early illness, indicating a potential avenue for anti-inflammatory interventions that simultaneously address high rates of metabolic disease in this population. The aim of this study is to design a novel anti-inflammatory diet intervention (DI) that is feasible to implement in a first-episode psychosis (FEP) population. METHODS: Eligible FEP Participants are aged 15-30. The DI is currently being refined through a multi-phase process that includes the recruitment of focus groups that provide insight into feasibility of measures and nutritional education, as well as the implementation of the DI. The phases in the study are the Development Phase, Formative Phase, and the Feasibility Phase. RESULTS: The Development phase has resulted in the creation of a flexible DI for FEP based on existing research on nutritional health and informed by providers. This study has just completed the Formative phase, recruiting eligible participants to join focus groups that gleaned information about dietary habits, preferences, and food environments to further refine the DI. CONCLUSION: Findings from earlier phases have advised the current Feasibility Phase in which this novel DI is being administered to a small cohort of FEP participants (N = 12) to determine acceptability of the DI from a lived experience perspective. Naturalistic changes in inflammatory biomarkers, metabolic health, and symptoms will also be measured.

Study Links
Quality Scores
SafetyNot Assessed
Efficacy50/10
Quality60/10
Research Impact Scores
APT Score0.05
Weight Score2.06
Normalized Score0.52
Related Supplements
Development of an anti-inflammatory diet for first-episode p... | Panacea Index