Development of an anti-inflammatory diet for first-episode psychosis (FEP): a feasibility study protocol.
Study Goal
The researchers aimed to design and assess the feasibility of an anti-inflammatory diet intervention for individuals with first-episode psychosis (FEP) to address inflammation and metabolic health.
Results Summary
The study developed a flexible anti-inflammatory diet based on existing research and refined it through focus groups. The feasibility phase is currently testing acceptability and measuring changes in inflammatory biomarkers, metabolic health, and symptoms, but results are preliminary.
Population
First-episode psychosis (FEP) participants aged 15-30.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
anti-inflammatory diet intervention (DI) | decrease | high rates of metabolic disease | first-episode psychosis (FEP) population | - | address | #1 |
anti-inflammatory diet intervention (DI) | neutral | acceptability of the DI | small cohort of FEP participants (N = 12) | - | administered | #2 |
anti-inflammatory diet intervention (DI) | neutral | naturalistic changes in inflammatory biomarkers | small cohort of FEP participants (N = 12) | - | measured | #3 |
anti-inflammatory diet intervention (DI) | neutral | naturalistic changes in metabolic health | small cohort of FEP participants (N = 12) | - | measured | #4 |
anti-inflammatory diet intervention (DI) | neutral | naturalistic changes in symptoms | small cohort of FEP participants (N = 12) | - | measured | #5 |
BACKGROUND: Evidence suggests inflammation plays a role in the pathophysiology of psychosis even in early illness, indicating a potential avenue for anti-inflammatory interventions that simultaneously address high rates of metabolic disease in this population. The aim of this study is to design a novel anti-inflammatory diet intervention (DI) that is feasible to implement in a first-episode psychosis (FEP) population. METHODS: Eligible FEP Participants are aged 15-30. The DI is currently being refined through a multi-phase process that includes the recruitment of focus groups that provide insight into feasibility of measures and nutritional education, as well as the implementation of the DI. The phases in the study are the Development Phase, Formative Phase, and the Feasibility Phase. RESULTS: The Development phase has resulted in the creation of a flexible DI for FEP based on existing research on nutritional health and informed by providers. This study has just completed the Formative phase, recruiting eligible participants to join focus groups that gleaned information about dietary habits, preferences, and food environments to further refine the DI. CONCLUSION: Findings from earlier phases have advised the current Feasibility Phase in which this novel DI is being administered to a small cohort of FEP participants (N = 12) to determine acceptability of the DI from a lived experience perspective. Naturalistic changes in inflammatory biomarkers, metabolic health, and symptoms will also be measured.