Exploring the therapeutic potential of silymarin-based herbal remedy (prebiotic) and probiotic blend in a mouse model of NAFLD: Insights into gut microbiota modulation and liver health.
Study Goal
The researchers aimed to evaluate the effectiveness of a silymarin-based herbal remedy combined with probiotics in attenuating NAFLD progression in a mouse model.
Results Summary
The silymarin-piperine-fulvic acid herbal remedy and probiotic blend (F3) significantly reduced hepatic fat accumulation and improved gut microbiota composition in NAFLD mice. The treatment also lowered elevated lipids, liver enzymes, and glucose levels.
Population
NAFLD mouse model induced by a high-fat and high-fructose diet.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high-fat and high-fructose diet | increase | lipids | Mice on the high-fat diet | - | exhibited elevated | #1 |
high-fat and high-fructose diet | increase | liver enzymes | Mice on the high-fat diet | - | exhibited elevated | #2 |
high-fat and high-fructose diet | increase | glucose | Mice on the high-fat diet | - | exhibited elevated | #3 |
high-fat and high-fructose diet | decrease | high-density lipoprotein levels | Mice on the high-fat diet | - | reduced | #4 |
F3 (silymarin-piperine-fulvic acid herbal remedy and probiotic blend) | decrease | hepatic fat accumulation | NAFLD mouse model | - | significantly reduced | #5 |
F3 (silymarin-piperine-fulvic acid herbal remedy and probiotic blend) | increase | gut microbiota composition | NAFLD mouse model | - | improved | #6 |
Non-alcoholic fatty liver disease (NAFLD) is a significant consequence of metabolic dysfunction, often associated with changes in the intestinal microbiota. Prebiotics and probiotics have shown promise in NAFLD management. This study evaluated a silymarin-based herbal remedy with piperine and fulvic acid, alongside a probiotic blend of Bifidobacterium adolescentis, Bifidobacterium bifidum, Lactobacillus casei, and Lactobacillus rhamnosus. Using a NAFLD mouse model induced by a high-fat and high-fructose diet, we assessed biochemical parameters, liver function, glucose levels, and conducted histological analysis. Stool samples underwent 16S rRNA metagenomic analysis to explore changes in microbiota composition. Mice on the high-fat diet exhibited elevated lipids, liver enzymes, and glucose, with reduced high-density lipoprotein levels (with p value < 0.001). Treatment, particularly with F3 (silymarin-piperine-fulvic acid herbal remedy and probiotic blend), significantly reduced hepatic fat accumulation and improved gut microbiota composition. This study highlights the potential of silymarin-based therapy combined with probiotics in attenuating NAFLD progression.