MicroRNAs and the Mediterranean diet: a nutri-omics perspective for lung cancer.
Study Goal
The researchers aimed to examine the benefits of the Mediterranean Diet in protecting against non-communicable diseases, particularly lung cancer, and its interaction with smoking habits.
Results Summary
The study highlighted the Mediterranean Diet's anti-inflammatory effects and its potential role in reducing lung cancer risk, especially in conjunction with smoking cessation. It also discussed the broader impact of extending MedDiet benefits globally and the potential of personalized nutrition and nutri-omics in lung cancer prevention.
Population
General population, with a focus on smokers and individuals at risk for lung cancer.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
unhealthy diet | increase | lung cancer risk | - | - | joint effect with smoking in lung cancer risk increase | #1 |
Mediterranean Diet (MedDiet) | decrease | some non-communicable diseases including lung cancer | - | - | protecting against | #2 |
Mediterranean Diet (MedDiet) | decrease | inflammation | - | - | anti-inflammatory effect | #3 |
Mediterranean Diet (MedDiet) | neutral | risk of lung cancer | - | - | interaction with smoking habits | #4 |
Planeterranean extension of the benefits of MedDiet | decrease | lung cancer risk | global | - | could have on controlling | #5 |
personalized nutrition | neutral | lung cancer prevention | - | - | impact on | #6 |
microRNAs (miRNAs) | neutral | lung cancer prevention | - | - | promising nutritional molecular hub for | #7 |
Lung cancer is the deadliest cancer type worldwide with ~ 1.8 million deaths per-year. Smoking accounts for ~ 85% of all cases, with a described joint effect with unhealthy diet in lung cancer risk increase. Public health policies to prevent carcinogens exposure, promote smoking cessation and advocacy for healthy nutrition, are therefore highly recommended. Here we have examined the benefits of the Mediterranean Diet (MedDiet) in protecting against some non-communicable diseases including lung cancer, highlighting the epidemiological and biomolecular aspects of MedDiet anti-inflammatory effect and its interaction with smoking habits closely linked to risk of lung cancer. Considering the high incidence and mortality rates of lung cancer, we discussed also about the global impact that a Planeterranean extension of the benefits of MedDiet could have on controlling lung cancer risk. We also debated the impact of personalized nutrition on lung cancer prevention, considering individual heterogeneity in response to diet plans as well as recent advancements on nutri-omics in lung cancer research, with a specific focus on the role of microRNAs (miRNAs) as a promising nutritional molecular hub for lung cancer prevention. We strongly believe that a deep understanding of the molecular link between food components and genetic/epigenetics factors can expand effective intervention strategies.