Greater adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with lower risk of inflammatory bowel disease: a prospective cohort study.
Study Goal
The researchers aimed to determine the association between adherence to the MIND diet (a hybrid of the Mediterranean and DASH diets) and the risk of developing inflammatory bowel disease (IBD).
Results Summary
Greater adherence to the MIND diet was associated with a lower risk of IBD, Crohn's disease, and ulcerative colitis, with hazard ratios indicating a 26% reduced risk for IBD. The associations were partially mediated by metabolic and inflammation status.
Population
187,490 participants from the UK Biobank, average age 56.2 years, 55.0% female, free of IBD at baseline.
Effective Dosage
Not specified (dietary intake assessed via 24-hour recall questionnaire).
Duration
Mean follow-up of 10.7 years.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
greater adherence to the MIND diet | decrease | IBD | 187,490 participants in the UK Biobank | HRcomparing extreme tertiles 0.74, 95% CI 0.62-0.90, p = 0.002 | was associated with a lower risk | #1 |
greater adherence to the MIND diet | decrease | Crohn's disease (CD) | 187,490 participants in the UK Biobank | HR 0.66, 95% CI 0.47-0.94, p = 0.022 | was associated with a lower risk | #2 |
greater adherence to the MIND diet | decrease | ulcerative colitis (UC) | 187,490 participants in the UK Biobank | HR 0.78, 95% CI 0.62-0.98, p = 0.031 | was associated with a lower risk | #3 |
greater adherence to the MIND diet | neutral | metabolic and inflammation status | 187,490 participants in the UK Biobank | mediation proportion: 5.5-15.9% | associations were partially mediated by | #4 |
Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is emerging as a promising candidate for preventive measures against inflammatory bowel disease (IBD), though there is currently no direct evidence from population-based studies. This study aims to bridge the gap in understanding of the association of the MIND diet with IBD risk. Methods: We utilized data from 187 490 participants in the UK Biobank who provided dietary information and were free of IBD at baseline. Dietary information was obtained using a validated web-based 24-hour dietary recall questionnaire. A MIND diet score was evaluated based on the intake of ten beneficial and five unhealthy food groups and the scores were further grouped into tertiles. The outcome of interest was incident IBD, Crohn's disease (CD), and ulcerative colitis (UC). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models adjusted for demographic characteristics, lifestyle factors, cancer history, and other dietary factors. Mediation analyses were performed to evaluate the role of systemic inflammation and metabolic disorders represented by the integrated biomarkers in the MIND diet-IBD association. Results: After a mean follow-up of 10.7 years, we documented 825 incident IBD cases (250 CD and 575 UC). The average age of the participants was 56.2 years, of which 55.0% were females. We found that greater adherence to the MIND diet, represented by a higher diet score, was associated with a lower risk of IBD (HRcomparing extreme tertiles 0.74, 95% CI 0.62-0.90, p = 0.002; p for trend = 0.005), CD (HR 0.66, 95% CI 0.47-0.94, p = 0.022; p for trend = 0.023), and UC (HR 0.78, 95% CI 0.62-0.98, p = 0.031; p for trend = 0.022). The associations were partially mediated by metabolic and inflammation status (mediation proportion: 5.5-15.9%). Conclusion: We found higher adherence to the MIND diet was associated with a lower risk of IBD, and that inflammatory and metabolic conditions may play an important role in the underlying mechanistic pathways.