The Role of Licorice Chalcones as Molecular Genes and Signaling Pathways Modulator-A Review of Experimental Implications for Nicotine-Induced Non-Small Cell Lung Cancer Treatment.
Study Goal
The researchers aimed to review experimental studies on the effects and potential mechanisms of licorice chalcones in nicotine-induced non-small cell lung cancer (NSCLC) treatment.
Results Summary
The abstract indicates that licorice chalcones exhibit pharmacological effects, including anticancer properties, but the specific mechanisms in nicotine-induced NSCLC remain unknown. The study reviews existing experimental data but does not present new findings.
Population
Not specified (in vitro and/or in vivo experiments mentioned, but no human population detailed).
Effective Dosage
Not provided
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Nicotine | increase | lung cancer (LC) | - | - | stimulates progression | #1 |
Nicotine | increase | non-small cell lung cancer (NSCLC) | - | - | stimulates | #2 |
licorice chalcones (CHs) treatment | increase | antioxidant effects | - | - | exhibits | #3 |
licorice chalcones (CHs) treatment | decrease | anti-inflammatory effects | - | - | exhibits | #4 |
licorice chalcones (CHs) treatment | decrease | anticancer effects | - | - | exhibits | #5 |
Lung cancer (LC) represents the leading cause of global cancer deaths, with cigarette smoking being considered a major risk factor. Nicotine is a major hazardous compound in cigarette smoke (CS), which stimulates LC progression and non-small cell lung cancer (NSCLC) specifically through activation of the nicotinic acetylcholine receptor (α7nAChR)-mediated cell-signaling pathways and molecular genes involved in proliferation, angiogenesis, and metastasis. Chalcones (CHs) and their derivatives are intermediate plant metabolites involved in flavonol biosynthesis. Isoliquiritigenin (ILTG), licochalcone A-E (LicoA-E), and echinatin (ECH) are the most common natural CHs isolated from the root of Glycyrrhiza (also known as licorice). In vitro and/or vivo experiments have shown that licorice CHs treatment exhibits a range of pharmacological effects, including antioxidant, anti-inflammatory, and anticancer effects. Despite advances in NSCLC treatment, the mechanisms of licorice CHs in nicotine-induced NSCLC treatment remain unknown. Therefore, the aim of this paper is to review experimental studies through the PubMed/Medline database that reveal the effects of licorice CHs and their potential mechanisms in nicotine-induced NSCLC treatment.