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Anthocyanins and Type 2 Diabetes: An Update of Human Study and Clinical Trial.

Nutrients
January 1, 1970
Aleksandra Kozłowska et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the therapeutic effects of dietary anthocyanins from fruits and vegetables on diabetes-related outcomes, including glucose regulation and inflammation reduction.

Results Summary

The study found that anthocyanin supplementation improved fasting blood glucose levels, glycated hemoglobin, and other diabetes-related indicators, with higher dosages showing more favorable effects. An anthocyanin-rich diet was associated with better diabetes outcomes, particularly in at-risk groups.

Population

Individuals with or at risk of type 2 diabetes.

Effective Dosage

Increased dosages were noted as more effective, but specific amounts and frequencies were not provided.

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (10)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Anthocyanins
decrease
glucose level
pre-clinical studies under diabetic conditions
-
role in glucose level regulation
#1
Anthocyanins
increase
gut microbiota
pre-clinical studies under diabetic conditions
-
gut microbiota improvement
#2
Anthocyanins
decrease
inflammation
pre-clinical studies under diabetic conditions
-
inflammation reduction
#3
incorporating these research advancements into clinical practice
increase
prevention and management of type 2 diabetes
-
-
significantly improve the prevention and management
#4
dietary anthocyanins
increase
diabetes
-
-
therapeutic effects
#5
Anthocyanin supplementation
decrease
fasting blood glucose levels
-
-
regulatory effect
#6
Anthocyanin supplementation
decrease
glycated hemoglobin
-
-
regulatory effect
#7
Anthocyanin supplementation
decrease
other diabetes-related indicators
-
-
regulatory effect
#8
increased anthocyanin dosages
increase
diabetes treatment
-
-
more favorable implications
#9
anthocyanin-rich diet
increase
diabetes outcomes
at-risk groups
-
improve
#10
Abstract

Anthocyanins are phenolic compounds occurring in fruits and vegetables. Evidence from pre-clinical studies indicates their role in glucose level regulation, gut microbiota improvement, and inflammation reduction under diabetic conditions. Therefore, incorporating these research advancements into clinical practice would significantly improve the prevention and management of type 2 diabetes. This narrative review provides a concise overview of 18 findings from recent clinical research published over the last 5 years that investigate the therapeutic effects of dietary anthocyanins on diabetes. Anthocyanin supplementation has been shown to have a regulatory effect on fasting blood glucose levels, glycated hemoglobin, and other diabetes-related indicators. Furthermore, increased anthocyanin dosages had more favorable implications for diabetes treatment. This review provides evidence that an anthocyanin-rich diet can improve diabetes outcomes, especially in at-risk groups. Future research should focus on optimal intervention duration, consider multiple clinical biomarkers, and analyze anthocyanin effects among well-controlled versus poorly controlled groups of patients with diabetes.

Medical Subject Headings (MeSH)
HumansAnthocyaninsDiabetes Mellitus, Type 2Blood GlucoseGlycated HemoglobinDietary SupplementsFruitClinical Trials as TopicGastrointestinal Microbiome
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations3
Citations/Year3.0
Research Impact Scores
APT Score0.25
Weight Score1.46
Normalized Score0.69
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Anthocyanins and Type 2 Diabetes: An Update of Human Study a... | Panacea Index