Association between Mediterranean-dietary approaches to stop hypertension intervention for neurodegenerative delay diet and biomarkers of oxidative stress, metabolic factors, disease severity, and odds of disease in rheumatoid arthritis patients.
Study Goal
The researchers aimed to examine the association between the MIND dietary pattern (a hybrid of Mediterranean and DASH diets) and oxidative stress indicators, metabolic factors, disease activity, and the odds of rheumatoid arthritis (RA).
Results Summary
The study found that higher adherence to the MIND diet was associated with lower odds of RA, reduced disease activity, improved lipid profiles, and better blood glucose status, but no significant link with oxidative stress factors.
Population
101 patients with rheumatoid arthritis and 101 healthy individuals.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
MIND dietary pattern | decrease | MIND diet score | RA subjects | - | average score was substantially lower | #1 |
MIND dietary pattern | decrease | odds of RA | Individuals with a higher MIND diet score | - | had lower odds | #2 |
MIND dietary pattern | no change | oxidative stress factors | - | - | no remarkable link | #3 |
MIND dietary pattern | decrease | disease activity | - | - | reverse association | #4 |
MIND dietary pattern | decrease | triglycerides | - | - | significantly and negatively correlated | #5 |
MIND dietary pattern | decrease | low-density lipoprotein cholesterol | - | - | significantly and negatively correlated | #6 |
MIND dietary pattern | decrease | total cholesterol | - | - | significantly and negatively correlated | #7 |
MIND dietary pattern | decrease | fasting blood glucose | - | - | significantly and negatively correlated | #8 |
MIND dietary pattern | decrease | hemoglobin A1C | - | - | significantly and negatively correlated | #9 |
MIND dietary pattern | increase | high-density lipoprotein cholesterol | - | - | positive association | #10 |
MIND diet | decrease | disease activity | - | - | may decrease | #11 |
MIND diet | decrease | odds of RA | - | - | may decrease | #12 |
MIND diet | increase | lipid profile | RA patients | - | may improve | #13 |
MIND diet | increase | blood glucose status | RA patients | - | may improve | #14 |
This research aimed to examine the association between the following Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern and oxidative stress indicators, metabolic factors, disease activity, and the odds of disease in patients with rheumatoid arthritis (RA). In this cross-sectional study, we included 101 patients with RA and 101 healthy individuals. The MIND diet score was measured using a semi-quantitative Food Frequency Questionnaire (FFQ) with 147 food items. Total capacity antioxidant (TCA), superoxide dismutase (SOD), glutathione peroxidase (GPX), and malondialdehyde (MDA) serum concentrations were evaluated by ELISA, and the disease severity was measured regarding the disease activity score 28 (DAS-28) criteria. The average score of the MIND diet was substantially lower in the RA subjects than in the healthy people (p < .001). Individuals with a higher MIND diet score had lower odds of RA than those with a low score (p < .001). There was no remarkable link between the MIND diet and oxidative stress factors (p > .05). A reverse association was found between the MIND diet score and disease activity (p < .05). The MIND diet was significantly and negatively correlated with triglycerides, low-density lipoprotein cholesterol, total cholesterol, fasting blood glucose, and hemoglobin A1C. There was a positive association between the diet and high-density lipoprotein cholesterol. The findings indicate that following the MIND diet may decrease disease activity and the odds of RA. Also, high adherence to the MIND diet may improve the lipid profile and blood glucose status in RA patients.