Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial.
Study Goal
The researchers aimed to determine whether combining the Mediterranean diet with curcumin supplementation could reduce disease activity, inflammation, and improve quality of life in patients with mild-to-moderate ulcerative colitis.
Results Summary
The study found that the Mediterranean diet combined with curcumin supplementation was effective in reducing disease activity and inflammation while improving quality of life in individuals with ulcerative colitis.
Population
Patients with mild-to-moderate active ulcerative colitis.
Effective Dosage
1600 mg/day of curcumin supplementation.
Duration
8 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean diet (MD) | decrease | disease activity | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in reducing | #1 |
Mediterranean diet (MD) | decrease | inflammation | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in reducing | #2 |
Mediterranean diet (MD) | increase | quality of life | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in improving | #3 |
MD + curcumin | decrease | disease activity | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in reducing | #4 |
MD + curcumin | decrease | inflammation | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in reducing | #5 |
MD + curcumin | increase | quality of life | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in improving | #6 |
MD + resveratrol | decrease | disease activity | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in reducing | #7 |
MD + resveratrol | decrease | inflammation | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in reducing | #8 |
MD + resveratrol | increase | quality of life | patients with mild-to-moderate active ulcerative colitis (UC) | - | effective in improving | #9 |
This study aimed to investigate the effects of the Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis (UC). This study was designed as a prospective multicenter three-arm randomized controlled trial. Participants were randomized to the MD, MD + curcumin, and MD + resveratrol groups. All participants were placed on the MD for 8 weeks. The MD + curcumin group also received 1600 mg/day of curcumin supplementation, whereas the MD + resveratrol group received 500 mg/day of resveratrol supplementation for 8 weeks. Anthropometric measurements, Truelove-Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Mediterranean Diet Adherence Scale (MEDAS), and laboratory tests were performed at baseline and postintervention. Within-group comparisons showed that MD, MD + curcumin, and MD + resveratrol interventions were effective in reducing disease activity and inflammation and improving quality of life in individuals with UC (